4cyg

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==The structure of vanin-1: defining the link between metabolic disease, oxidative stress and inflammation==
==The structure of vanin-1: defining the link between metabolic disease, oxidative stress and inflammation==
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<StructureSection load='4cyg' size='340' side='right' caption='[[4cyg]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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<StructureSection load='4cyg' size='340' side='right'caption='[[4cyg]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4cyg]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CYG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4CYG FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4cyg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CYG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CYG FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=RRV:(2R)-2,4-DIHYDROXY-N-[(3S)-3-HYDROXY-4-PHENYLBUTYL]-3,3-DIMETHYLBUTANAMIDE'>RRV</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4cyf|4cyf]], [[4cyu|4cyu]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=RRV:(2R)-2,4-DIHYDROXY-N-[(3S)-3-HYDROXY-4-PHENYLBUTYL]-3,3-DIMETHYLBUTANAMIDE'>RRV</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Pantetheine_hydrolase Pantetheine hydrolase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.92 3.5.1.92] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cyg OCA], [https://pdbe.org/4cyg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cyg RCSB], [https://www.ebi.ac.uk/pdbsum/4cyg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cyg ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4cyg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cyg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4cyg RCSB], [http://www.ebi.ac.uk/pdbsum/4cyg PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/VNN1_HUMAN VNN1_HUMAN]] Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.<ref>PMID:10567687</ref> <ref>PMID:11491533</ref>
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[https://www.uniprot.org/uniprot/VNN1_HUMAN VNN1_HUMAN] Amidohydrolase that hydrolyzes specifically one of the carboamide linkages in D-pantetheine thus recycling pantothenic acid (vitamin B5) and releasing cysteamine.<ref>PMID:10567687</ref> <ref>PMID:11491533</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4cyg" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Pantetheine hydrolase]]
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[[Category: Homo sapiens]]
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[[Category: Adams, T E]]
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[[Category: Large Structures]]
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[[Category: Boersma, Y L]]
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[[Category: Adams TE]]
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[[Category: Bozaoglu, K]]
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[[Category: Boersma YL]]
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[[Category: Cowieson, N]]
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[[Category: Bozaoglu K]]
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[[Category: Krippner, G]]
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[[Category: Cowieson N]]
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[[Category: Lucent, D]]
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[[Category: Krippner G]]
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[[Category: Newman, J]]
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[[Category: Lucent D]]
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[[Category: Peat, T S]]
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[[Category: Newman J]]
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[[Category: Sparrow, L]]
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[[Category: Peat TS]]
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[[Category: Coa biosynthesis]]
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[[Category: Sparrow L]]
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[[Category: Colitis]]
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[[Category: Hydrolase]]
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[[Category: Inflammation]]
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[[Category: Oxidative stress]]
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The structure of vanin-1: defining the link between metabolic disease, oxidative stress and inflammation

PDB ID 4cyg

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