2mz6
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==NMR structure of Protegrin-3 (PG3) in the presence of DPC micelles== | |
| + | <StructureSection load='2mz6' size='340' side='right'caption='[[2mz6]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2mz6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MZ6 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 1 model</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mz6 OCA], [https://pdbe.org/2mz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mz6 RCSB], [https://www.ebi.ac.uk/pdbsum/2mz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mz6 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PG3_PIG PG3_PIG] Microbicidal activity. Active against E.coli, Listeria monocytogenes and C.albicans, in vitro. | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | A tendency to dimerize in the presence of lipids was found for the protegrin. The dimer formation by the protegrin-1 (PG-1) is the first step for further oligomeric membrane pore formation. Generally there are two distinct model of PG-1 dimerization in either a parallel or antiparallel beta-sheet. But despite the wealth of data available today, protegrin dimer structure and pore formation is still not completely understood. In order to investigate a more detailed dimerization process of PG-1 and if it will be the same for another type of protegrins, in this work we used a high-resolution NMR spectroscopy for structure determination of protegrin-3 (RGGGL-CYCRR-RFCVC-VGR) in the presence of perdeuterated DPC micelles and demonstrate that PG-3 forms an antiparallel NCCN dimer with a possible association of these dimers. This structural study complements previously published solution, solid state and computational studies of PG-1 in various environments and validate the potential of mean force simulations of PG-1 dimers and association of dimers to form octameric or decameric beta-barrels. | ||
| - | + | Antimicrobial peptide protegrin-3 adopt an antiparallel dimer in the presence of DPC micelles: a high-resolution NMR study.,Usachev KS, Efimov SV, Kolosova OA, Klochkova EA, Aganov AV, Klochkov VV J Biomol NMR. 2015 Mar 19. PMID:25786621<ref>PMID:25786621</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: Aganov | + | <div class="pdbe-citations 2mz6" style="background-color:#fffaf0;"></div> |
| - | [[Category: Efimov | + | |
| - | [[Category: | + | ==See Also== |
| - | [[Category: Klochkova | + | *[[Protegrin|Protegrin]] |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Sus scrofa]] | ||
| + | [[Category: Aganov AV]] | ||
| + | [[Category: Efimov SV]] | ||
| + | [[Category: Klochkov VV]] | ||
| + | [[Category: Klochkova EA]] | ||
| + | [[Category: Kolosova OA]] | ||
| + | [[Category: Usachev KS]] | ||
Current revision
NMR structure of Protegrin-3 (PG3) in the presence of DPC micelles
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