4y71

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(New page: '''Unreleased structure''' The entry 4y71 is ON HOLD Authors: Convery, M.A., Young, R.J., Senger, S., Hamblin, J.N., Chan, C., Toomey, J.R., Watson, N.S. Description: [[Category: Unre...)
Current revision (10:53, 10 January 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 4y71 is ON HOLD
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==Factor Xa complex with GTC000398==
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<StructureSection load='4y71' size='340' side='right'caption='[[4y71]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4y71]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y71 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Y71 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=48W:6-CHLORO-N-{(3S)-1-[(2S)-1-(4-METHYL-5-OXO-1,4-DIAZEPAN-1-YL)-1-OXOPROPAN-2-YL]-2-OXOPYRROLIDIN-3-YL}NAPHTHALENE-2-SULFONAMIDE'>48W</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4y71 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y71 OCA], [https://pdbe.org/4y71 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4y71 RCSB], [https://www.ebi.ac.uk/pdbsum/4y71 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4y71 ProSAT]</span></td></tr>
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</table>
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== Disease ==
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[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN] Defects in F10 are the cause of factor X deficiency (FA10D) [MIM:[https://omim.org/entry/227600 227600]. A hemorrhagic disease with variable presentation. Affected individuals can manifest prolonged nasal and mucosal hemorrhage, menorrhagia, hematuria, and occasionally hemarthrosis. Some patients do not have clinical bleeding diathesis.<ref>PMID:2790181</ref> <ref>PMID:1973167</ref> <ref>PMID:1985698</ref> <ref>PMID:7669671</ref> <ref>PMID:8529633</ref> <ref>PMID:7860069</ref> <ref>PMID:8845463</ref> <ref>PMID:8910490</ref> <ref>PMID:10468877</ref> <ref>PMID:10746568</ref> <ref>PMID:10739379</ref> <ref>PMID:11248282</ref> <ref>PMID:11728527</ref> <ref>PMID:12945883</ref> <ref>PMID:15650540</ref> <ref>PMID:17393015</ref> <ref>PMID:19135706</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/FA10_HUMAN FA10_HUMAN] Factor Xa is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting.
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Authors: Convery, M.A., Young, R.J., Senger, S., Hamblin, J.N., Chan, C., Toomey, J.R., Watson, N.S.
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==See Also==
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*[[Factor Xa|Factor Xa]]
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Description:
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Senger, S]]
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__TOC__
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[[Category: Toomey, J.R]]
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</StructureSection>
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[[Category: Hamblin, J.N]]
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[[Category: Homo sapiens]]
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[[Category: Watson, N.S]]
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[[Category: Large Structures]]
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[[Category: Young, R.J]]
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[[Category: Chan C]]
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[[Category: Convery, M.A]]
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[[Category: Convery MA]]
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[[Category: Chan, C]]
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[[Category: Hamblin JN]]
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[[Category: Senger S]]
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[[Category: Toomey JR]]
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[[Category: Watson NS]]
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[[Category: Young RJ]]

Current revision

Factor Xa complex with GTC000398

PDB ID 4y71

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