5aj3

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(New page: '''Unreleased structure''' The entry 5aj3 is ON HOLD until sometime in the future Authors: Greber, B.J., Bieri, P., Leibundgut, M., Leitner, A., Aebersold, R., Boehringer, D., Ban, N. ...)
Current revision (08:42, 23 October 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 5aj3 is ON HOLD until sometime in the future
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==Structure of the small subunit of the mammalian mitoribosome==
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<SX load='5aj3' size='340' side='right' viewer='molstar' caption='[[5aj3]], [[Resolution|resolution]] 3.60&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5aj3]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AJ3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AJ3 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=P5P:PURINE+RIBOSIDE-5-MONOPHOSPHATE'>P5P</scene>, <scene name='pdbligand=Y5P:1-(5-O-PHOSPHONO-BETA-D-RIBOFURANOSYL)-1,4-DIHYDROPYRIMIDINE'>Y5P</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5aj3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aj3 OCA], [https://pdbe.org/5aj3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5aj3 RCSB], [https://www.ebi.ac.uk/pdbsum/5aj3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5aj3 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/F1S001_PIG F1S001_PIG]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Mammalian mitochondrial ribosomes (mitoribosomes) synthesize mitochondrially encoded membrane proteins that are critical for mitochondrial function. Here we present the complete atomic structure of the porcine 55S mitoribosome at 3.8 angstrom resolution by cryo-electron microscopy and chemical cross-linking/mass spectrometry. The structure of the 28S subunit in the complex was resolved at 3.6 angstrom resolution by focused alignment, which allowed building of a detailed atomic structure including all of its 15 mitoribosomal-specific proteins. The structure reveals the intersubunit contacts in the 55S mitoribosome, the molecular architecture of the mitoribosomal messenger RNA (mRNA) binding channel and its interaction with transfer RNAs, and provides insight into the highly specialized mechanism of mRNA recruitment to the 28S subunit. Furthermore, the structure contributes to a mechanistic understanding of aminoglycoside ototoxicity.
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Authors: Greber, B.J., Bieri, P., Leibundgut, M., Leitner, A., Aebersold, R., Boehringer, D., Ban, N.
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Ribosome. The complete structure of the 55S mammalian mitochondrial ribosome.,Greber BJ, Bieri P, Leibundgut M, Leitner A, Aebersold R, Boehringer D, Ban N Science. 2015 Apr 17;348(6232):303-8. doi: 10.1126/science.aaa3872. Epub 2015 Apr, 2. PMID:25837512<ref>PMID:25837512</ref>
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Description: Structure of the small subunit of the mammalian mitoribosome
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Leitner, A]]
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<div class="pdbe-citations 5aj3" style="background-color:#fffaf0;"></div>
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[[Category: Greber, B.J]]
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[[Category: Aebersold, R]]
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==See Also==
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[[Category: Boehringer, D]]
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*[[Ribosome 3D structures|Ribosome 3D structures]]
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[[Category: Leibundgut, M]]
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*[[Transfer RNA (tRNA)|Transfer RNA (tRNA)]]
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[[Category: Ban, N]]
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== References ==
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[[Category: Bieri, P]]
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<references/>
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__TOC__
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</SX>
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[[Category: Large Structures]]
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[[Category: Sus scrofa]]
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[[Category: Aebersold R]]
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[[Category: Ban N]]
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[[Category: Bieri P]]
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[[Category: Boehringer D]]
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[[Category: Greber BJ]]
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[[Category: Leibundgut M]]
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[[Category: Leitner A]]

Current revision

Structure of the small subunit of the mammalian mitoribosome

5aj3, resolution 3.60Å

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OCA

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