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4rmj
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==Human Sirt2 in complex with ADP ribose and nicotinamide== | ==Human Sirt2 in complex with ADP ribose and nicotinamide== | ||
| - | <StructureSection load='4rmj' size='340' side='right' caption='[[4rmj]], [[Resolution|resolution]] 1.87Å' scene=''> | + | <StructureSection load='4rmj' size='340' side='right'caption='[[4rmj]], [[Resolution|resolution]] 1.87Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4rmj]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RMJ OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4rmj]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RMJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4RMJ FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AR6:[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL+[HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL]+HYDROGEN+PHOSPHATE'>AR6</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NCA:NICOTINAMIDE'>NCA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.87Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AR6:[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL+[HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL]+HYDROGEN+PHOSPHATE'>AR6</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NCA:NICOTINAMIDE'>NCA</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4rmj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rmj OCA], [https://pdbe.org/4rmj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4rmj RCSB], [https://www.ebi.ac.uk/pdbsum/4rmj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4rmj ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/SIR2_HUMAN SIR2_HUMAN] NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates 'Lys-310' of RELA.<ref>PMID:12620231</ref> <ref>PMID:12697818</ref> <ref>PMID:21081649</ref> <ref>PMID:21726808</ref> |
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| - | + | ==See Also== | |
| - | + | *[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]] | |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Einsle | + | [[Category: Homo sapiens]] |
| - | [[Category: Gajer | + | [[Category: Large Structures]] |
| - | [[Category: Gerhardt | + | [[Category: Einsle O]] |
| - | [[Category: Jung | + | [[Category: Gajer M]] |
| - | [[Category: Karaman | + | [[Category: Gerhardt S]] |
| - | [[Category: Ladwein | + | [[Category: Jung M]] |
| - | [[Category: Lehotzky | + | [[Category: Karaman B]] |
| - | [[Category: North | + | [[Category: Ladwein KI]] |
| - | [[Category: Olah | + | [[Category: Lehotzky A]] |
| - | [[Category: Ovadi | + | [[Category: North BJ]] |
| - | [[Category: Pannek | + | [[Category: Olah J]] |
| - | [[Category: Roessler | + | [[Category: Ovadi J]] |
| - | [[Category: Rumpf | + | [[Category: Pannek M]] |
| - | [[Category: Schiedel | + | [[Category: Roessler C]] |
| - | [[Category: Schmidtkunz | + | [[Category: Rumpf T]] |
| - | [[Category: Schutkowski | + | [[Category: Schiedel M]] |
| - | [[Category: Sinclair | + | [[Category: Schmidtkunz K]] |
| - | [[Category: Sippl | + | [[Category: Schutkowski M]] |
| - | [[Category: Steegborn | + | [[Category: Sinclair DA]] |
| - | + | [[Category: Sippl W]] | |
| + | [[Category: Steegborn C]] | ||
Current revision
Human Sirt2 in complex with ADP ribose and nicotinamide
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Categories: Homo sapiens | Large Structures | Einsle O | Gajer M | Gerhardt S | Jung M | Karaman B | Ladwein KI | Lehotzky A | North BJ | Olah J | Ovadi J | Pannek M | Roessler C | Rumpf T | Schiedel M | Schmidtkunz K | Schutkowski M | Sinclair DA | Sippl W | Steegborn C
