This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5aik
From Proteopedia
(Difference between revisions)
(New page: ==Human DYRK1A in complex with LDN-211898== <StructureSection load='5aik' size='340' side='right' caption='5aik, resolution 2.70Å' scene=''> == Structural highligh...) |
|||
| (6 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| + | |||
==Human DYRK1A in complex with LDN-211898== | ==Human DYRK1A in complex with LDN-211898== | ||
| - | <StructureSection load='5aik' size='340' side='right' caption='[[5aik]], [[Resolution|resolution]] 2.70Å' scene=''> | + | <StructureSection load='5aik' size='340' side='right'caption='[[5aik]], [[Resolution|resolution]] 2.70Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5aik]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AIK OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5aik]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AIK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AIK FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AWR:4-(7-METHOXY-1-(TRIFLUOROMETHYL)-9H-PYRIDO[3,4-B]INDOL-9-YL)BUTAN-1-AMINE'>AWR</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=AWR:4-(7-METHOXY-1-(TRIFLUOROMETHYL)-9H-PYRIDO[3,4-B]INDOL-9-YL)BUTAN-1-AMINE'>AWR</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=PTR:O-PHOSPHOTYROSINE'>PTR</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5aik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aik OCA], [https://pdbe.org/5aik PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5aik RCSB], [https://www.ebi.ac.uk/pdbsum/5aik PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5aik ProSAT]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN] Defects in DYRK1A are the cause of mental retardation autosomal dominant type 7 (MRD7) [MIM:[https://omim.org/entry/614104 614104]. A disease characterized by primary microcephaly, severe mental retardation without speech, anxious autistic behavior, and dysmorphic features, including bitemporal narrowing, deep-set eyes, large simple ears, and a pointed nasal tip. Mental retardation is characterized by significantly below average general intellectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.<ref>PMID:21294719</ref> |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/DYR1A_HUMAN DYR1A_HUMAN] May play a role in a signaling pathway regulating nuclear functions of cell proliferation. Phosphorylates serine, threonine and tyrosine residues in its sequence and in exogenous substrates.<ref>PMID:8769099</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Bountra | + | [[Category: Large Structures]] |
| - | [[Category: Cuny | + | [[Category: Bountra C]] |
| - | [[Category: Edwards | + | [[Category: Cuny G]] |
| - | [[Category: Elkins | + | [[Category: Edwards A]] |
| - | [[Category: Higgins | + | [[Category: Elkins JM]] |
| - | [[Category: Knapp | + | [[Category: Higgins J]] |
| - | [[Category: Muniz | + | [[Category: Knapp S]] |
| - | [[Category: Soundararajan | + | [[Category: Muniz JRC]] |
| - | + | [[Category: Soundararajan M]] | |
| - | + | ||
| - | + | ||
Current revision
Human DYRK1A in complex with LDN-211898
| |||||||||||
Categories: Homo sapiens | Large Structures | Bountra C | Cuny G | Edwards A | Elkins JM | Higgins J | Knapp S | Muniz JRC | Soundararajan M
