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5ail
From Proteopedia
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==Human PARP9 2nd macrodomain== | ==Human PARP9 2nd macrodomain== | ||
| - | <StructureSection load='5ail' size='340' side='right' caption='[[5ail]], [[Resolution|resolution]] 1.55Å' scene=''> | + | <StructureSection load='5ail' size='340' side='right'caption='[[5ail]], [[Resolution|resolution]] 1.55Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[5ail]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AIL OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[5ail]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AIL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AIL FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=15P:POLYETHYLENE+GLYCOL+(N=34)'>15P</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene> | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.55Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=15P:POLYETHYLENE+GLYCOL+(N=34)'>15P</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ail FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ail OCA], [https://pdbe.org/5ail PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ail RCSB], [https://www.ebi.ac.uk/pdbsum/5ail PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ail ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/PARP9_HUMAN PARP9_HUMAN] Overexpressed at significantly higher levels in fatal high-risk diffuse large B-cell lymphomas (DLB-CL) compared to cured low-risk tumors. Overexpression in B-cell lymphoma transfectants may promote malignant B-cell migration. May therefore be involved in promoting B-cell migration and dissemination of high-risk DLB-CL tumors. |
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/PARP9_HUMAN PARP9_HUMAN] In concert with DTX3L plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9/BAL1-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites. Involved in inducing the expression of IFN-gamma-responsive genes.<ref>PMID:16809771</ref> <ref>PMID:23230272</ref> |
| + | |||
| + | ==See Also== | ||
| + | *[[Poly(ADP-ribose) polymerase 3D structures|Poly(ADP-ribose) polymerase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Arrowsmith C]] |
| - | [[Category: Edwards | + | [[Category: Bountra C]] |
| - | [[Category: Elkins | + | [[Category: Edwards AM]] |
| - | [[Category: Knapp | + | [[Category: Elkins JM]] |
| - | [[Category: Shrestha | + | [[Category: Knapp S]] |
| - | [[Category: Sieg | + | [[Category: Shrestha L]] |
| - | [[Category: Sorrell | + | [[Category: Sieg C]] |
| - | [[Category: Talon | + | [[Category: Sorrell F]] |
| - | [[Category: Williams | + | [[Category: Talon R]] |
| - | [[Category: | + | [[Category: Williams E]] |
| + | [[Category: Von Delft F]] | ||
Current revision
Human PARP9 2nd macrodomain
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Categories: Homo sapiens | Large Structures | Arrowsmith C | Bountra C | Edwards AM | Elkins JM | Knapp S | Shrestha L | Sieg C | Sorrell F | Talon R | Williams E | Von Delft F
