4kc1

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==Structure of the blood group glycosyltransferase AAglyB in complex with a pyridine inhibitor as a neutral pyrophosphate surrogate==
==Structure of the blood group glycosyltransferase AAglyB in complex with a pyridine inhibitor as a neutral pyrophosphate surrogate==
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<StructureSection load='4kc1' size='340' side='right' caption='[[4kc1]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
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<StructureSection load='4kc1' size='340' side='right'caption='[[4kc1]], [[Resolution|resolution]] 1.50&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4kc1]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KC1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4KC1 FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4kc1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4KC1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4KC1 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=BHE:OCTYL+2-O-(6-DEOXY-ALPHA-L-GALACTOPYRANOSYL)-BETA-D-GALACTOPYRANOSIDE'>BHE</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=WS1:6-(1-BETA-D-GLUCOPYRANOSYLOXYMETHYL)-N-(5-DEOXYLURIDINE-5-YL)PICOLINAMIDE'>WS1</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.5&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4kc4|4kc4]], [[4kc2|4kc2]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BHE:OCTYL+2-O-(6-DEOXY-ALPHA-L-GALACTOPYRANOSYL)-BETA-D-GALACTOPYRANOSIDE'>BHE</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=WS1:6-(1-BETA-D-GLUCOPYRANOSYLOXYMETHYL)-N-(5-DEOXYLURIDINE-5-YL)PICOLINAMIDE'>WS1</scene></td></tr>
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ABO ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4kc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kc1 OCA], [https://pdbe.org/4kc1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4kc1 RCSB], [https://www.ebi.ac.uk/pdbsum/4kc1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4kc1 ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4kc1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4kc1 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4kc1 RCSB], [http://www.ebi.ac.uk/pdbsum/4kc1 PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN]] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
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[https://www.uniprot.org/uniprot/BGAT_HUMAN BGAT_HUMAN] This protein is the basis of the ABO blood group system. The histo-blood group ABO involves three carbohydrate antigens: A, B, and H. A, B, and AB individuals express a glycosyltransferase activity that converts the H antigen to the A antigen (by addition of UDP-GalNAc) or to the B antigen (by addition of UDP-Gal), whereas O individuals lack such activity.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4kc1" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Glycosyltransferase 3D structures|Glycosyltransferase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Cuesta-Seijo, J A]]
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[[Category: Large Structures]]
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[[Category: Lafont, D]]
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[[Category: Cuesta-Seijo JA]]
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[[Category: Palcic, M M]]
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[[Category: Lafont D]]
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[[Category: Vidal, S]]
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[[Category: Palcic MM]]
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[[Category: Wang, S]]
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[[Category: Vidal S]]
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[[Category: Adp-gal]]
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[[Category: Wang S]]
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[[Category: Adp-galnac]]
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[[Category: Blood group protein]]
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[[Category: Fuc-gal]]
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[[Category: Glycosyltransferase]]
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[[Category: Gta superfanily]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Structure of the blood group glycosyltransferase AAglyB in complex with a pyridine inhibitor as a neutral pyrophosphate surrogate

PDB ID 4kc1

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