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4uem

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==UCH-L5 in complex with the RPN13 DEUBAD domain==
==UCH-L5 in complex with the RPN13 DEUBAD domain==
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<StructureSection load='4uem' size='340' side='right' caption='[[4uem]], [[Resolution|resolution]] 2.82&Aring;' scene=''>
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<StructureSection load='4uem' size='340' side='right'caption='[[4uem]], [[Resolution|resolution]] 2.82&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4uem]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UEM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4UEM FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4uem]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UEM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UEM FirstGlance]. <br>
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</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4uel|4uel]], [[4uf5|4uf5]], [[4uf6|4uf6]]</td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.82&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Ubiquitinyl_hydrolase_1 Ubiquitinyl hydrolase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.19.12 3.4.19.12] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uem OCA], [https://pdbe.org/4uem PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uem RCSB], [https://www.ebi.ac.uk/pdbsum/4uem PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uem ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4uem FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uem OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4uem RCSB], [http://www.ebi.ac.uk/pdbsum/4uem PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/UCHL5_HUMAN UCHL5_HUMAN]] Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.<ref>PMID:16906146</ref> <ref>PMID:18922472</ref> [[http://www.uniprot.org/uniprot/ADRM1_HUMAN ADRM1_HUMAN]] Functions as a proteasomal ubiquitin receptor. Recruits the deubiquitinating enzyme UCHL5 at the 26S proteasome and promotes its activity.<ref>PMID:16990800</ref> <ref>PMID:17139257</ref> <ref>PMID:16815440</ref> <ref>PMID:16906146</ref> <ref>PMID:18497817</ref>
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[https://www.uniprot.org/uniprot/UCHL5_HUMAN UCHL5_HUMAN] Protease that specifically cleaves 'Lys-48'-linked polyubiquitin chains. Deubiquitinating enzyme associated with the 19S regulatory subunit of the 26S proteasome. Putative regulatory component of the INO80 complex; however is inactive in the INO80 complex and is activated by a transient interaction of the INO80 complex with the proteasome via ADRM1.<ref>PMID:16906146</ref> <ref>PMID:18922472</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4uem" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Thioesterase 3D structures|Thioesterase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Ubiquitinyl hydrolase 1]]
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[[Category: Homo sapiens]]
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[[Category: Dijk, W J.Van]]
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[[Category: Large Structures]]
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[[Category: Ekkebus, R]]
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[[Category: Ekkebus R]]
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[[Category: Oualid, F El]]
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[[Category: El Oualid F]]
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[[Category: Ovaa, H]]
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[[Category: Ovaa H]]
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[[Category: Sahtoe, D D]]
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[[Category: Sahtoe DD]]
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[[Category: Sixma, T K]]
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[[Category: Sixma TK]]
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[[Category: Deubiquitinating enzyme]]
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[[Category: Van Dijk WJ]]
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[[Category: Dub]]
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[[Category: Hydrolase]]
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[[Category: Proteasome]]
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Current revision

UCH-L5 in complex with the RPN13 DEUBAD domain

PDB ID 4uem

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