2n06

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'''Unreleased structure'''
 
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The entry 2n06 is ON HOLD
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==Mdmx-298==
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<StructureSection load='2n06' size='340' side='right'caption='[[2n06]]' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2n06]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N06 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N06 FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=44Z:4-[[(4S,5R)-5-(4-CHLOROPHENYL)-4-(3-METHOXYPHENYL)-2-(4-METHOXY-2-PROPAN-2-YLOXY-PHENYL)-4,5-DIHYDROIMIDAZOL-1-YL]CARBONYL]PIPERAZIN-2-ONE'>44Z</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n06 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n06 OCA], [https://pdbe.org/2n06 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n06 RCSB], [https://www.ebi.ac.uk/pdbsum/2n06 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n06 ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MDM4_HUMAN MDM4_HUMAN] Inhibits p53/TP53- and TP73/p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Inhibits degradation of MDM2. Can reverse MDM2-targeted degradation of TP53 while maintaining suppression of TP53 transactivation and apoptotic functions.<ref>PMID:16163388</ref> <ref>PMID:16511572</ref>
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Authors: Grace, C.R., Kriwacki, R.W.
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==See Also==
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*[[MDM4|MDM4]]
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Description: MDMX-298
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Kriwacki, R.W]]
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__TOC__
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[[Category: Grace, C.R]]
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Grace CR]]
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[[Category: Kriwacki RW]]

Current revision

Mdmx-298

PDB ID 2n06

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