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2n07

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(New page: '''Unreleased structure''' The entry 2n07 is ON HOLD Authors: Yu, R., Seymour, V., Berecki, G., Jia, X., Akcan, M., Adams, D., Kaas, Q., Craik, D. Description: Design of a Highly Stabl...)
Current revision (18:57, 29 November 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 2n07 is ON HOLD
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==Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic alpha-Conotoxin Vc1.1==
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<StructureSection load='2n07' size='340' side='right'caption='[[2n07]]' scene=''>
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Authors: Yu, R., Seymour, V., Berecki, G., Jia, X., Akcan, M., Adams, D., Kaas, Q., Craik, D.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[2n07]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Conus_victoriae Conus victoriae]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N07 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N07 FirstGlance]. <br>
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Description: Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic alpha-Conotoxin Vc1.1
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n07 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n07 OCA], [https://pdbe.org/2n07 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n07 RCSB], [https://www.ebi.ac.uk/pdbsum/2n07 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n07 ProSAT]</span></td></tr>
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[[Category: Jia, X]]
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</table>
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[[Category: Berecki, G]]
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== Function ==
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[[Category: Craik, D]]
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[https://www.uniprot.org/uniprot/CA1A_CONVC CA1A_CONVC] Alpha-conotoxins act on postsynaptic membranes, they bind to the nicotinic acetylcholine receptors (nAChR) and thus inhibit them. This synthetic peptide (produced without hydroxyproline, nor 4-carboxyglutamate) is a neuronal nAChR antagonist that acts as a powerful analgesic. It blocks nAChRs composed of alpha-3 or -5/beta-2 (IC(50)=7.2 uM), alpha-3/beta-2 (IC(50)=7.3 uM), alpha-3/beta-4 (IC(50)=4.2 uM), alpha-3 or -5/beta-4 (IC(50)<30 uM), alpha-4/beta-2 (IC(50)<30 uM), alpha-4/beta-4 (IC(50)<30 uM) and alpha/beta/gamma/delta (IC(50)<30 uM) subunits.<ref>PMID:12779345</ref> <ref>PMID:15770155</ref>
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[[Category: Kaas, Q]]
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== References ==
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[[Category: Yu, R]]
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<references/>
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[[Category: Akcan, M]]
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__TOC__
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[[Category: Adams, D]]
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</StructureSection>
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[[Category: Seymour, V]]
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[[Category: Conus victoriae]]
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[[Category: Large Structures]]
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[[Category: Adams D]]
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[[Category: Akcan M]]
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[[Category: Berecki G]]
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[[Category: Craik D]]
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[[Category: Jia X]]
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[[Category: Kaas Q]]
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[[Category: Seymour V]]
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[[Category: Yu R]]

Current revision

Design of a Highly Stable Disulfide-Deleted Mutant of Analgesic Cyclic alpha-Conotoxin Vc1.1

PDB ID 2n07

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