4yih
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4yih is ON HOLD Authors: Pachl, P., Rezacova, P., Brynda, J. Description: Crystal structure of human cytosolic 5'(3')-deoxyribonucleotidase in comp...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of human cytosolic 5'(3')-deoxyribonucleotidase in complex with the inhibitor PB-PVU== | |
| - | + | <StructureSection load='4yih' size='340' side='right'caption='[[4yih]], [[Resolution|resolution]] 1.82Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4yih]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YIH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YIH FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.82Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2O2:1-{2-DEOXY-3,5-O-[PHENYL(PHOSPHONO)METHYLIDENE]-BETA-D-THREO-PENTOFURANOSYL}-5-[(E)-2-PHOSPHONOETHENYL]PYRIMIDINE-2,4(1H,3H)-DIONE'>2O2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> |
| - | [[Category: Brynda | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yih FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yih OCA], [https://pdbe.org/4yih PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yih RCSB], [https://www.ebi.ac.uk/pdbsum/4yih PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yih ProSAT]</span></td></tr> |
| - | [[Category: Pachl | + | </table> |
| - | [[Category: Rezacova | + | == Function == |
| + | [https://www.uniprot.org/uniprot/NT5C_HUMAN NT5C_HUMAN] Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Brynda J]] | ||
| + | [[Category: Pachl P]] | ||
| + | [[Category: Rezacova P]] | ||
Current revision
Crystal structure of human cytosolic 5'(3')-deoxyribonucleotidase in complex with the inhibitor PB-PVU
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