2qsq

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[[Image:2qsq.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of the N-terminal domain of carcinoembryonic antigen (CEA)==
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|PDB= 2qsq |SIZE=350|CAPTION= <scene name='initialview01'>2qsq</scene>, resolution 1.95&Aring;
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<StructureSection load='2qsq' size='340' side='right'caption='[[2qsq]], [[Resolution|resolution]] 1.95&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Cl+Binding+Site+For+Residue+B+501'>AC1</scene>, <scene name='pdbsite=AC2:Cl+Binding+Site+For+Residue+A+502'>AC2</scene>, <scene name='pdbsite=AC3:Gol+Binding+Site+For+Residue+B+201'>AC3</scene>, <scene name='pdbsite=AC4:Gol+Binding+Site+For+Residue+A+202'>AC4</scene>, <scene name='pdbsite=AC5:Gol+Binding+Site+For+Residue+A+203'>AC5</scene> and <scene name='pdbsite=AC6:Gol+Binding+Site+For+Residue+A+204'>AC6</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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<table><tr><td colspan='2'>[[2qsq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QSQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2QSQ FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.95&#8491;</td></tr>
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|GENE= CEACAM5, CEA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2qsq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qsq OCA], [https://pdbe.org/2qsq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2qsq RCSB], [https://www.ebi.ac.uk/pdbsum/2qsq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2qsq ProSAT]</span></td></tr>
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</table>
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'''Crystal structure of the N-terminal domain of carcinoembryonic antigen (CEA)'''
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== Function ==
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[https://www.uniprot.org/uniprot/CEAM5_HUMAN CEAM5_HUMAN] Cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. Receptor for E.coli Dr adhesins.<ref>PMID:10864933</ref>
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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Carcinoembryonic antigen (CEA)-related cell adhesion molecules (CEACAMs) are host receptors for the Dr family of adhesins of Escherichia coli. To define the mechanism for binding of Dr adhesins to CEACAM receptors, we carried out structural studies on the N-terminal domain of CEA and its complex with the Dr adhesin. The crystal structure of CEA reveals a dimer similar to other dimers formed by receptors with IgV-like domains. The structure of the CEA/Dr adhesin complex is proposed based on NMR spectroscopy and mutagenesis data in combination with biochemical characterization. The Dr adhesin/CEA interface overlaps appreciably with the region responsible for CEA dimerization. Binding kinetics, mutational analysis and spectroscopic examination of CEA dimers suggest that Dr adhesins can dissociate CEA dimers prior to the binding of monomeric forms. Our conclusions include a plausible mechanism for how E. coli, and perhaps other bacterial and viral pathogens, exploit CEACAMs. The present structure of the complex provides a powerful tool for the design of novel inhibitory strategies to treat E. coli infections.
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/qs/2qsq_consurf.spt"</scriptWhenChecked>
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2QSQ is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2QSQ OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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==Reference==
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</jmolCheckbox>
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Binding of Dr adhesins of Escherichia coli to carcinoembryonic antigen triggers receptor dissociation., Korotkova N, Yang Y, Le Trong I, Cota E, Demeler B, Marchant J, Thomas WE, Stenkamp RE, Moseley SL, Matthews S, Mol Microbiol. 2008 Jan;67(2):420-34. Epub 2007 Dec 11. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18086185 18086185]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2qsq ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Korotkova, N.]]
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[[Category: Korotkova N]]
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[[Category: Moseley, S L.]]
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[[Category: Le Trong I]]
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[[Category: Stenkamp, R E.]]
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[[Category: Moseley SL]]
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[[Category: Trong, I Le.]]
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[[Category: Stenkamp RE]]
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[[Category: CL]]
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[[Category: GOL]]
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[[Category: cell adhesion]]
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[[Category: glycoprotein]]
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[[Category: gpi-anchor]]
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[[Category: immunoglobulin domain]]
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[[Category: lipoprotein]]
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[[Category: membrane]]
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[[Category: polymorphism]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:29:10 2008''
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Current revision

Crystal structure of the N-terminal domain of carcinoembryonic antigen (CEA)

PDB ID 2qsq

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