Cluster of Differentiation CD38

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Current revision (13:16, 10 July 2018) (edit) (undo)
 
(19 intermediate revisions not shown.)
Line 1: Line 1:
-
{{STRUCTURE_3gc6| PDB=3gc6 | SIZE=400| SCENE=Cluster_of_Differentiation_38/Cv/1 |right|CAPTION=Glycosylated Cluster of Differentiation 38 (CD38) complex with sulfate [[3gc6]] }}
+
<StructureSection load='2i65' size='450' side='right' scene='42/422415/Cv/3' caption='Human Cluster of Differentiation 38 (CD38) complex with NAD [[2i65]]'>
-
[[Cluster of Differentiation 38]] (CD38), known also as ''ADP-ribosyl cyclase 1'' (ADPRC1), catalyzes the synthesis and hydrolysis of cyclic ADP-ribose from NAD+ to ADP-ribose (ADPR). It is found on the surface of immune cells. It also functions in cell adhesion, signal transduction and Ca++ signaling.
+
__TOC__
-
{{TOC limit|limit=2}}
+
== Function ==
 +
[[Cluster of Differentiation 38]] (CD38), known also as '''ADP-ribosyl cyclase 1''' (ADPRC1), catalyzes the synthesis and hydrolysis of cyclic ADP-ribose from NAD+ to ADP-ribose (ADPR). It is found on the surface of immune cells. It also functions in cell adhesion, signal transduction and Ca+2 signaling. '''ADP-ribosyl cyclase''' (ADPRC) is the ''Aplysia californica'' homolog of CD38. It catalyzes the synthesis and hydrolysis of cyclic ADP-ribose. It uses NAD+ as substrate and produces cyclic ADP-ribose (cADPR).<ref>PMID:16154090</ref>
 +
 +
== Relevance ==
 +
 +
CD38 is used as a marker for cell activation and for leukemia.
 +
 +
== Structural highlights ==
 +
 +
<scene name='42/422415/Cv/4'>CD38 active site contains NAD</scene>.<ref>PMID:16951430</ref>
 +
</StructureSection>
== 3D Structures of Cluster of Differentiation 38 ==
== 3D Structures of Cluster of Differentiation 38 ==
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
 +
{{#tree:id=OrganizedByTopic|openlevels=0|
-
=== CD38 ===
+
* CD38
-
[[3gc6]] – bCD38 - bovine<br />
+
**[[3gc6]] – bCD38 - bovine<br />
-
[[3gh3]], [[3ghh]] – bCD38 residues 32-278<br />
+
**[[3gh3]], [[3ghh]] – bCD38 residues 32-278<br />
-
[[2eg9]] - CD38 enzymatic domain (mutant) – mouse<br />
+
**[[2eg9]] - CD38 enzymatic domain (mutant) – mouse<br />
-
[[2ef1]] - hCD38 enzymatic domain – human<br />
+
**[[2ef1]] - hCD38 enzymatic domain – human<br />
-
[[1yh3]] - hCD38 enzymatic domain (mutant)<br />
+
**[[1yh3]] - hCD38 enzymatic domain (mutant)<br />
-
[[1zvm]] - hCD38 (mutant)<br />
+
**[[1zvm]] - hCD38 (mutant)<br />
**[[1isf]] – hADPRC2 (mutant) <br />
**[[1isf]] – hADPRC2 (mutant) <br />
-
=== CD38+ligand ===
+
* CD38+ligand
 +
 
 +
**[[3i9m]], [[3i9n]] – hCD38 enzymatic domain+ADPR analog<br />
 +
**[[3f6y]] – hCD38 enzymatic domain+Ca++<br />
 +
**[[3dzf]] - hCD38 enzymatic domain+intermediate<br />
 +
**[[3dzg]] - hCD38 enzymatic domain (mutant)+intermediate/nicotinamide complex<br />
 +
**[[3dzh]] - hCD38 enzymatic domain (mutant)+GTP<br />
 +
**[[3dzi]] - hCD38 enzymatic domain (mutant)+intermediate/GTP complex<br />
 +
**[[3dzj]], [[3dzk]] - hCD38 enzymatic domain (mutant)+NMN complex<br />
 +
**[[2pgj]], [[2pgl]] - hCD38 enzymatic domain (mutant)+substrate analog<br />
 +
**[[2o3t]] - hCD38 enzymatic domain (mutant)+cGDPR<br />
 +
**[[3u4h]], [[3u4i]] - hCD38 enzymatic domain (mutant)+cIDPR<br />
 +
**[[2o3u]] - hCD38 enzymatic domain (mutant)+NGD <br />
 +
**[[2o3q]], [[2o3r]], [[2o3s]] - hCD38 enzymatic domain (mutant)+cADPR<br />
 +
**[[4f45]] - hCD38 enzymatic domain (mutant)+ NAADP<br />
 +
**[[4f46]] - hCD38 enzymatic domain (mutant)+ NAADP + ADPRP<br />
 +
**[[4cmh]] - hCD38 enzymatic domain + antibody<br />
 +
**[[2i65]] – hCD38+NAD<br />
 +
**[[3kou]] - hCD38+NAD derivative<br />
 +
**[[2i67]] - hCD38 (mutant)+ADPR<br />
 +
**[[2hct]] - hCD38 enzymatic domain (mutant)+NMN<br />
 +
**[[3ofs]] - hCD38 enzymatic domain (mutant)+ ARA-2 F-ADPR<br />
 +
**[[3raj]] - hCD38 enzymatic domain (mutant)+ FAB<br />
 +
**[[3rok]], [[3rom]] - hCD38 (mutant) + arabinitol derivative<br />
 +
**[[3roq]] - hCD38 (mutant) + hydrofuran derivative<br />
 +
**[[3rop]] - hCD38 (mutant) + arabinitol derivative + nicotinamide<br />
 +
**[[3p5s]] - bADPRC + arabinitol derivative<br />
 +
 
 +
*ADPRC
 +
 
 +
**[[1r12]] - AcADPRC - ''Aplysia californica''<br />
 +
**[[1r0s]] – AcADPRC (mutant) <br />
 +
 
 +
*ADPRC+ligand
 +
 
 +
**[[1r15]] - AcADPRC+nicotinamide<br />
 +
**[[3i9j]] – AcADPRC+nicotinamide+2F-NAD+2F-ADPRI<br />
 +
**[[3i9k]] – AcADPRC (mutant)+NAD<br />
 +
**[[3i9l]] – AcADPRC (mutant)+N1-CIDPR<br />
 +
**[[3i9o]] – AcADPRC+Ribosyl-2F-ADPR<br />
 +
**[[3zwx]], [[3zwy]] – AcADPRC + 8-Br-ADPR<br />
 +
**[[1r16]] - AcADPRC+3-pyridinylcarbinol<br />
 +
**[[3zwm]] – AcADPRC + NAD + cADPR<br />
 +
**[[3zwn]] – AcADPRC + NGD + cGDPR<br />
 +
**[[3zwo]] – AcADPRC + NGD + GDPR<br />
 +
**[[3zwp]], [[3zwv]], [[3zww]] – AcADPRC+ diphosphate ribosyl ara-2F-ADPR<br />
 +
 
-
[[3i9m]], [[3i9n]] – hCD38 enzymatic domain+ADPR analog<br />
+
}}
-
[[3f6y]] – hCD38 enzymatic domain+Ca++<br />
+
== References ==
-
[[3dzf]] - hCD38 enzymatic domain+intermediate<br />
+
<references/>
-
[[3dzg]] - hCD38 enzymatic domain (mutant)+intermediate/nicotinamide complex<br />
+
-
[[3dzh]] - hCD38 enzymatic domain (mutant)+GTP<br />
+
-
[[3dzi]] - hCD38 enzymatic domain (mutant)+intermediate/GTP complex<br />
+
-
[[3dzj]], [[3dzk]] - hCD38 enzymatic domain (mutant)+NMN complex<br />
+
-
[[2pgj]], [[2pgl]] - hCD38 enzymatic domain (mutant)+substrate analog<br />
+
-
[[2o3t]] - hCD38 enzymatic domain (mutant)+cGDPR<br />
+
-
[[3u4h]], [[3u4i]] - hCD38 enzymatic domain (mutant)+cIDPR<br />
+
-
[[2o3u]] - hCD38 enzymatic domain (mutant)+NGD <br />
+
-
[[2o3q]], [[2o3r]], [[2o3s]] - hCD38 enzymatic domain (mutant)+cADPR<br />
+
-
[[4f45]] - hCD38 enzymatic domain (mutant)+ NAADP<br />
+
-
[[4f46]] - hCD38 enzymatic domain (mutant)+ NAADP + ADPRP<br />
+
-
[[2i65]] – hCD38+NAD<br />
+
-
[[2i66]] - hCD38 (mutant)+GDP intermediate<br />
+
-
[[2i67]] - hCD38 (mutant)+ADPR<br />
+
-
[[2hct]] - hCD38 enzymatic domain (mutant)+NMN<br />
+
-
[[3ofs]] - hCD38 enzymatic domain (mutant)+ ARA-2 F-ADPR<br />
+
-
[[3raj]] - hCD38 enzymatic domain (mutant)+ FAB<br />
+
-
[[3rok]], [[3rom]] - hCD38 (mutant) + arabinitol derivative<br />
+
-
[[3roq]] - hCD38 (mutant) + hydrofuran derivative<br />
+
-
[[3rop]] - hCD38 (mutant) + arabinitol derivative + nicotinamide<br />
+
-
[[1isf]] – hCD38 (mutant)<br />
+
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Human Cluster of Differentiation 38 (CD38) complex with NAD 2i65

Drag the structure with the mouse to rotate

3D Structures of Cluster of Differentiation 38

Updated on 10-July-2018

References

  1. ↑ Liu Q, Kriksunov IA, Graeff R, Munshi C, Lee HC, Hao Q. Crystal structure of human CD38 extracellular domain. Structure. 2005 Sep;13(9):1331-9. PMID:16154090 doi:http://dx.doi.org/10.1016/j.str.2005.05.012
  2. ↑ Liu Q, Kriksunov IA, Graeff R, Munshi C, Lee HC, Hao Q. Structural basis for the mechanistic understanding of human CD38-controlled multiple catalysis. J Biol Chem. 2006 Oct 27;281(43):32861-9. Epub 2006 Sep 2. PMID:16951430 doi:10.1074/jbc.M606365200

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Jaime Prilusky

Retrieved from "http://52.214.119.220/wiki/index.php/Cluster_of_Differentiation_CD38"
Personal tools