Cluster of Differentiation CD38
From Proteopedia
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| - | + | <StructureSection load='2i65' size='450' side='right' scene='42/422415/Cv/3' caption='Human Cluster of Differentiation 38 (CD38) complex with NAD [[2i65]]'> | |
| - | + | __TOC__ | |
| - | + | == Function == | |
| + | [[Cluster of Differentiation 38]] (CD38), known also as '''ADP-ribosyl cyclase 1''' (ADPRC1), catalyzes the synthesis and hydrolysis of cyclic ADP-ribose from NAD+ to ADP-ribose (ADPR). It is found on the surface of immune cells. It also functions in cell adhesion, signal transduction and Ca+2 signaling. '''ADP-ribosyl cyclase''' (ADPRC) is the ''Aplysia californica'' homolog of CD38. It catalyzes the synthesis and hydrolysis of cyclic ADP-ribose. It uses NAD+ as substrate and produces cyclic ADP-ribose (cADPR).<ref>PMID:16154090</ref> | ||
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| + | == Relevance == | ||
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| + | CD38 is used as a marker for cell activation and for leukemia. | ||
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| + | == Structural highlights == | ||
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| + | <scene name='42/422415/Cv/4'>CD38 active site contains NAD</scene>.<ref>PMID:16951430</ref> | ||
| + | </StructureSection> | ||
== 3D Structures of Cluster of Differentiation 38 == | == 3D Structures of Cluster of Differentiation 38 == | ||
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**[[4f45]] - hCD38 enzymatic domain (mutant)+ NAADP<br /> | **[[4f45]] - hCD38 enzymatic domain (mutant)+ NAADP<br /> | ||
**[[4f46]] - hCD38 enzymatic domain (mutant)+ NAADP + ADPRP<br /> | **[[4f46]] - hCD38 enzymatic domain (mutant)+ NAADP + ADPRP<br /> | ||
| + | **[[4cmh]] - hCD38 enzymatic domain + antibody<br /> | ||
**[[2i65]] – hCD38+NAD<br /> | **[[2i65]] – hCD38+NAD<br /> | ||
| + | **[[3kou]] - hCD38+NAD derivative<br /> | ||
**[[2i67]] - hCD38 (mutant)+ADPR<br /> | **[[2i67]] - hCD38 (mutant)+ADPR<br /> | ||
**[[2hct]] - hCD38 enzymatic domain (mutant)+NMN<br /> | **[[2hct]] - hCD38 enzymatic domain (mutant)+NMN<br /> | ||
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**[[3roq]] - hCD38 (mutant) + hydrofuran derivative<br /> | **[[3roq]] - hCD38 (mutant) + hydrofuran derivative<br /> | ||
**[[3rop]] - hCD38 (mutant) + arabinitol derivative + nicotinamide<br /> | **[[3rop]] - hCD38 (mutant) + arabinitol derivative + nicotinamide<br /> | ||
| - | **[[ | + | **[[3p5s]] - bADPRC + arabinitol derivative<br /> |
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| + | *ADPRC | ||
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| + | **[[1r12]] - AcADPRC - ''Aplysia californica''<br /> | ||
| + | **[[1r0s]] – AcADPRC (mutant) <br /> | ||
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| + | *ADPRC+ligand | ||
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| + | **[[1r15]] - AcADPRC+nicotinamide<br /> | ||
| + | **[[3i9j]] – AcADPRC+nicotinamide+2F-NAD+2F-ADPRI<br /> | ||
| + | **[[3i9k]] – AcADPRC (mutant)+NAD<br /> | ||
| + | **[[3i9l]] – AcADPRC (mutant)+N1-CIDPR<br /> | ||
| + | **[[3i9o]] – AcADPRC+Ribosyl-2F-ADPR<br /> | ||
| + | **[[3zwx]], [[3zwy]] – AcADPRC + 8-Br-ADPR<br /> | ||
| + | **[[1r16]] - AcADPRC+3-pyridinylcarbinol<br /> | ||
| + | **[[3zwm]] – AcADPRC + NAD + cADPR<br /> | ||
| + | **[[3zwn]] – AcADPRC + NGD + cGDPR<br /> | ||
| + | **[[3zwo]] – AcADPRC + NGD + GDPR<br /> | ||
| + | **[[3zwp]], [[3zwv]], [[3zww]] – AcADPRC+ diphosphate ribosyl ara-2F-ADPR<br /> | ||
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}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
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[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Current revision
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3D Structures of Cluster of Differentiation 38
Updated on 10-July-2018
References
- ↑ Liu Q, Kriksunov IA, Graeff R, Munshi C, Lee HC, Hao Q. Crystal structure of human CD38 extracellular domain. Structure. 2005 Sep;13(9):1331-9. PMID:16154090 doi:http://dx.doi.org/10.1016/j.str.2005.05.012
- ↑ Liu Q, Kriksunov IA, Graeff R, Munshi C, Lee HC, Hao Q. Structural basis for the mechanistic understanding of human CD38-controlled multiple catalysis. J Biol Chem. 2006 Oct 27;281(43):32861-9. Epub 2006 Sep 2. PMID:16951430 doi:10.1074/jbc.M606365200
