Cyclic GMP-AMP synthase

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<StructureSection load='4k97' size='340' side='right' caption='Structure of mouse cyclic GMP-AMP synthase C terminal complex with DNA, ATP, Mg+2 (green) and Zn+2 (grey) ions (PDB code [[4k97]]). ' scene='59/591942/Cv/1'>
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<StructureSection load='4o67' size='350' side='right' caption='Structure of human cyclic GMP-AMP synthase complex with c-GAMP and Zn+2 (grey) ions (PDB code [[4o67]]). ' scene='59/591942/Cv/2'>
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== Function ==
== Function ==
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'''Cyclic GMP-AMP synthase''' (CGAS) binds to DNA and catalyzes cGAMP synthesis. The cGAMP activates the type-I interferon pathway.
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'''Cyclic GMP-AMP synthase''' (CGAS) binds to DNA and catalyzes cGAMP synthesis. The cGAMP activates the type-I interferon pathway. <ref>PMID:23258413</ref>
== Disease ==
== Disease ==
Mice lacking CGAS are more vulnerable to lethal infection by DNA virus.
Mice lacking CGAS are more vulnerable to lethal infection by DNA virus.
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== Relevance ==
 
== Structural highlights ==
== Structural highlights ==
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</StructureSection>
 
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==3D structures of cyclic GMP-AMP synthase==
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The <scene name='59/591942/Cv/4'>2'3'-cGAMP binds at the lower part of the cleft between the N-lobe and C-lobe of CGAS</scene>.<ref>PMID:24462292</ref>
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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==3D structures of cyclic GMP-AMP structures==
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{{#tree:id=OrganizedByTopic|openlevels=0|
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[[Cyclic GMP-AMP synthase 3D structures]]
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*cyclic GMP-AMP synthase
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**[[4k8v]] – mCGAS C terminal – mouse<br />
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**[[4km5]], [[4mkp]], [[4lev]], [[4lew]], [[4o68]], [[4o69]] – hCGAS C terminal – human<br />
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**[[4jlx]] – pCGAS C terminal – pig<br />
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**[[4txy]] – VcCGAS – ''Vibrio cholerae''<br />
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**[[4u0l]], [[4u0n]] – VcCGAS (mutant)<br />
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*Cyclic GMP-AMP synthase complex
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**[[4k96]], [[4ley]], [[4lez]], [[4o6a]] – mCGAS C terminal + DNA<br />
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**[[4k97]] – mCGAS C terminal + DNA + ATP<br />
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**[[4k98]], [[4k99]], [[4k9a]], [[4k9b]] – mCGAS C terminal + DNA + polynucleotide<br />
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**[[4kb6]] – pCGAS C terminal + DNA + ATP + GTP <br />
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**[[4jlz]] – pCGAS C terminal + UTP<br />
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**[[4o67]] - hCGAS C terminal + cyclic GMP-AMP <br />
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**[[4txz]] – VcCGAS + GTP<br />
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**[[4ty0]] – VcCGAS + PPPAPG<br />
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**[[4u03]] – VcCGAS + GTP + 5MTHFGlu2<br />
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**[[4u0m]] – VcCGAS (mutant) + GTP + ATP + 5MTHFGlu2<br />
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}}
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</StructureSection>
== References ==
== References ==

Current revision

Structure of human cyclic GMP-AMP synthase complex with c-GAMP and Zn+2 (grey) ions (PDB code 4o67).

Drag the structure with the mouse to rotate

References

  1. ↑ Sun L, Wu J, Du F, Chen X, Chen ZJ. Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. Science. 2013 Feb 15;339(6121):786-91. doi: 10.1126/science.1232458. Epub 2012, Dec 20. PMID:23258413 doi:10.1126/science.1232458
  2. ↑ Zhang X, Wu J, Du F, Xu H, Sun L, Chen Z, Brautigam CA, Zhang X, Chen ZJ. The cytosolic DNA sensor cGAS forms an oligomeric complex with DNA and undergoes switch-like conformational changes in the activation loop. Cell Rep. 2014 Feb 13;6(3):421-30. doi: 10.1016/j.celrep.2014.01.003. Epub 2014, Jan 23. PMID:24462292 doi:http://dx.doi.org/10.1016/j.celrep.2014.01.003

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