4yhd
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Staphylococcal alpha-hemolysin H35A mutant monomer== | |
| + | <StructureSection load='4yhd' size='340' side='right'caption='[[4yhd]], [[Resolution|resolution]] 2.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4yhd]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YHD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YHD FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.801Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yhd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yhd OCA], [https://pdbe.org/4yhd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yhd RCSB], [https://www.ebi.ac.uk/pdbsum/4yhd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yhd ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/HLA_STAAU HLA_STAAU] Alpha-toxin binds to the membrane of eukaryotic cells resulting in the release of low-molecular weight molecules and leading to an eventual osmotic lysis. Heptamer oligomerization and pore formation is required for lytic activity. | ||
| - | + | ==See Also== | |
| - | + | *[[Hemolysin 3D structures|Hemolysin 3D structures]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Staphylococcus aureus]] |
| - | [[Category: | + | [[Category: Kato K]] |
| - | [[Category: Tanaka | + | [[Category: Sugawara T]] |
| + | [[Category: Tanaka Y]] | ||
| + | [[Category: Yao M]] | ||
Current revision
Staphylococcal alpha-hemolysin H35A mutant monomer
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