4ymx

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(New page: '''Unreleased structure''' The entry 4ymx is ON HOLD Authors: Ge, J., Yu, J., Yang, M. Description: Crystal structure of the substrate binding protein of an amino acid ABC transporter ...)
Current revision (15:36, 8 November 2023) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 4ymx is ON HOLD
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==Crystal structure of the substrate binding protein of an amino acid ABC transporter==
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<StructureSection load='4ymx' size='340' side='right'caption='[[4ymx]], [[Resolution|resolution]] 1.48&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4ymx]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Caldanaerobacter_subterraneus_subsp._tengcongensis_MB4 Caldanaerobacter subterraneus subsp. tengcongensis MB4]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YMX OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YMX FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.481&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ARG:ARGININE'>ARG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ymx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ymx OCA], [https://pdbe.org/4ymx PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ymx RCSB], [https://www.ebi.ac.uk/pdbsum/4ymx PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ymx ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/Q8RCC4_CALS4 Q8RCC4_CALS4]
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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ATP-binding cassette (ABC) transporters are ubiquitous integral membrane proteins that translocate a variety of substrates, ranging from ions to macromolecules, either out of or into the cytosol (hence defined as importers or exporters, respectively). It has been demonstrated that ABC exporters and importers function through a common mechanism involving conformational switches between inward-facing and outward-facing states; however, the mechanism underlying their functions, particularly substrate recognition, remains elusive. Here we report the structures of an amino acid ABC importer Art(QN)2 from Thermoanaerobacter tengcongensis composed of homodimers each of the transmembrane domain ArtQ and the nucleotide-binding domain ArtN, either in its apo form or in complex with substrates (Arg, His) and/or ATPs. The structures reveal that the straddling of the TMDs around the twofold axis forms a substrate translocation pathway across the membrane. Interestingly, each TMD has a negatively charged pocket that together create a negatively charged internal tunnel allowing amino acids carrying positively charged groups to pass through. Our structural and functional studies provide a better understanding of how ABC transporters select and translocate their substrates.
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Authors: Ge, J., Yu, J., Yang, M.
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Structural basis for substrate specificity of an amino acid ABC transporter.,Yu J, Ge J, Heuveling J, Schneider E, Yang M Proc Natl Acad Sci U S A. 2015 Apr 6. pii: 201415037. PMID:25848002<ref>PMID:25848002</ref>
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Description: Crystal structure of the substrate binding protein of an amino acid ABC transporter
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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[[Category: Yang, M]]
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<div class="pdbe-citations 4ymx" style="background-color:#fffaf0;"></div>
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[[Category: Ge, J]]
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== References ==
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[[Category: Yu, J]]
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Caldanaerobacter subterraneus subsp. tengcongensis MB4]]
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[[Category: Large Structures]]
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[[Category: Ge J]]
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[[Category: Yang M]]
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[[Category: Yu J]]

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Crystal structure of the substrate binding protein of an amino acid ABC transporter

PDB ID 4ymx

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