4yn8
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4yn8 is ON HOLD Authors: AKihiro, Doi, Hiro, Nakamura, Shiro, Yoshitsugu, Sugimoto, Hiroshi Description: Category: Unreleased Structures [[Cat...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of Response Regulator ChrA in Heme-Sensing Two Component System== | |
| + | <StructureSection load='4yn8' size='340' side='right'caption='[[4yn8]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4yn8]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Corynebacterium_diphtheriae Corynebacterium diphtheriae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YN8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YN8 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yn8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yn8 OCA], [https://pdbe.org/4yn8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yn8 RCSB], [https://www.ebi.ac.uk/pdbsum/4yn8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yn8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q9RPE9_CORDP Q9RPE9_CORDP] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | ChrA is a response regulator (RR) in the two-component system involved in regulating the degradation and transport of haem (Fe-porphyrin) in the pathogen Corynebacterium diphtheriae. Here, the crystal structure of full-length ChrA is described at a resolution of 1.8 A. ChrA consists of an N-terminal regulatory domain, a long linker region and a C-terminal DNA-binding domain. A structural comparison of ChrA with other RRs revealed substantial differences in the relative orientation of the two domains and the conformation of the linker region. The structural flexibility of the linker could be an important feature in rearrangement of the domain orientation to create a dimerization interface to bind DNA during haem-sensing signal transduction. | ||
| - | + | Structure of the response regulator ChrA in the haem-sensing two-component system of Corynebacterium diphtheriae.,Doi A, Nakamura H, Shiro Y, Sugimoto H Acta Crystallogr F Struct Biol Commun. 2015 Aug 1;71(Pt 8):966-71. doi:, 10.1107/S2053230X15009838. Epub 2015 Jul 29. PMID:26249683<ref>PMID:26249683</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 4yn8" style="background-color:#fffaf0;"></div> |
| + | |||
| + | ==See Also== | ||
| + | *[[Response regulator 3D structure|Response regulator 3D structure]] | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Corynebacterium diphtheriae]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Doi A]] | ||
| + | [[Category: Nakamura H]] | ||
| + | [[Category: Shiro Y]] | ||
| + | [[Category: Sugimoto H]] | ||
Current revision
Crystal Structure of Response Regulator ChrA in Heme-Sensing Two Component System
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