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4xxr
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==Atomic Resolution X-Ray Crystal Structure of a Ruthenocene Conjugated Beta-Lactam Antibiotic in Complex with CTX-M-14 E166A Beta-Lactamase== | ==Atomic Resolution X-Ray Crystal Structure of a Ruthenocene Conjugated Beta-Lactam Antibiotic in Complex with CTX-M-14 E166A Beta-Lactamase== | ||
| - | <StructureSection load='4xxr' size='340' side='right' caption='[[4xxr]], [[Resolution|resolution]] 1.18Å' scene=''> | + | <StructureSection load='4xxr' size='340' side='right'caption='[[4xxr]], [[Resolution|resolution]] 1.18Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4xxr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XXR OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4xxr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4XXR FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=JSC:[(1,2,3,4,5-ETA)-1-(4-{[CARBOXY(4-CARBOXY-5,5-DIMETHYL-1,3-THIAZOLIDIN-2-YL)METHYL]AMINO}-4-OXOBUTANOYL)CYCLOPENTADIENYL][(1,2,3,4,5-ETA)-CYCLOPENTADIENYL]RUTHENIUM'>JSC</scene>, <scene name='pdbligand=JSD:[(1,2,3,4,5-ETA)-1-(4-{[(4-CARBOXY-5,5-DIMETHYL-1,3-THIAZOLIDIN-2-YL)METHYL]AMINO}-4-OXOBUTANOYL)CYCLOPENTADIENYL][(1,2,3,4,5-ETA)-CYCLOPENTADIENYL]RUTHENIUM'>JSD</scene>, <scene name='pdbligand=JSE:[(1,2,3,4,5-ETA)-1-(4-{[CARBOXY(4-CARBOXY-5,5-DIMETHYL-1,3-THIAZOLIDIN-2-YL)METHYL]AMINO}-4-OXOBUTANOYL)CYCLOPENTADIENYL][(1,2,3,4,5-ETA)-CYCLOPENTADIENYL]RUTHENIUM'>JSE</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.18Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=JSC:[(1,2,3,4,5-ETA)-1-(4-{[CARBOXY(4-CARBOXY-5,5-DIMETHYL-1,3-THIAZOLIDIN-2-YL)METHYL]AMINO}-4-OXOBUTANOYL)CYCLOPENTADIENYL][(1,2,3,4,5-ETA)-CYCLOPENTADIENYL]RUTHENIUM'>JSC</scene>, <scene name='pdbligand=JSD:[(1,2,3,4,5-ETA)-1-(4-{[(4-CARBOXY-5,5-DIMETHYL-1,3-THIAZOLIDIN-2-YL)METHYL]AMINO}-4-OXOBUTANOYL)CYCLOPENTADIENYL][(1,2,3,4,5-ETA)-CYCLOPENTADIENYL]RUTHENIUM'>JSD</scene>, <scene name='pdbligand=JSE:[(1,2,3,4,5-ETA)-1-(4-{[CARBOXY(4-CARBOXY-5,5-DIMETHYL-1,3-THIAZOLIDIN-2-YL)METHYL]AMINO}-4-OXOBUTANOYL)CYCLOPENTADIENYL][(1,2,3,4,5-ETA)-CYCLOPENTADIENYL]RUTHENIUM'>JSE</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene></td></tr> | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4xxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xxr OCA], [https://pdbe.org/4xxr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4xxr RCSB], [https://www.ebi.ac.uk/pdbsum/4xxr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4xxr ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/Q9L5C7_ECOLX Q9L5C7_ECOLX] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 4xxr" style="background-color:#fffaf0;"></div> | ||
| + | |||
| + | ==See Also== | ||
| + | *[[Beta-lactamase 3D structures|Beta-lactamase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Escherichia coli]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Chen Y]] |
| - | [[Category: | + | [[Category: Lewandowski EM]] |
| - | + | ||
Current revision
Atomic Resolution X-Ray Crystal Structure of a Ruthenocene Conjugated Beta-Lactam Antibiotic in Complex with CTX-M-14 E166A Beta-Lactamase
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