2r1z

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[[Image:2r1z.gif|left|200px]]
 
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{{Structure
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==Crystal Structure of the BARD1 BRCT Repeat==
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|PDB= 2r1z |SIZE=350|CAPTION= <scene name='initialview01'>2r1z</scene>, resolution 2.100&Aring;
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<StructureSection load='2r1z' size='340' side='right'caption='[[2r1z]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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<table><tr><td colspan='2'>[[2r1z]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R1Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2R1Z FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
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|GENE= BARD1 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2r1z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2r1z OCA], [https://pdbe.org/2r1z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2r1z RCSB], [https://www.ebi.ac.uk/pdbsum/2r1z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2r1z ProSAT]</span></td></tr>
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</table>
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'''Crystal Structure of the BARD1 BRCT Repeat'''
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== Function ==
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[https://www.uniprot.org/uniprot/BARD1_HUMAN BARD1_HUMAN] Probable E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.<ref>PMID:10477523</ref> <ref>PMID:12890688</ref> <ref>PMID:14976165</ref> <ref>PMID:20351172</ref>
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== Evolutionary Conservation ==
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==Disease==
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[[Image:Consurf_key_small.gif|200px|right]]
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Known disease associated with this structure: Breast cancer, susceptibility to OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=601593 601593]]
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Check<jmol>
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<jmolCheckbox>
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==About this Structure==
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/r1/2r1z_consurf.spt"</scriptWhenChecked>
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2R1Z is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2R1Z OCA].
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2r1z ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Edwards, R A.]]
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[[Category: Edwards RA]]
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[[Category: Glover, M J.N.]]
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[[Category: Glover MJN]]
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[[Category: Lee, M S.]]
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[[Category: Lee MS]]
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[[Category: Williams, R S.]]
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[[Category: Williams RS]]
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[[Category: GOL]]
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[[Category: ank repeat]]
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[[Category: antitumor protein]]
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[[Category: brct repeat]]
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[[Category: disease mutation]]
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[[Category: metal-binding]]
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[[Category: nucleus]]
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[[Category: polymorphism]]
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[[Category: zinc]]
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[[Category: zinc-finger]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:31:46 2008''
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Current revision

Crystal Structure of the BARD1 BRCT Repeat

PDB ID 2r1z

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