4yqh

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m (Protected "4yqh" [edit=sysop:move=sysop])
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'''Unreleased structure'''
 
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The entry 4yqh is ON HOLD
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==2-[2-(4-Phenyl-1H-imidazol-2-yl)ethyl]quinoxaline (Sunovion Compound 14) co-crystallized with PDE10A==
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<StructureSection load='4yqh' size='340' side='right'caption='[[4yqh]], [[Resolution|resolution]] 2.31&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[4yqh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YQH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YQH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.308&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4F7:2-[2-(4-PHENYL-1H-IMIDAZOL-2-YL)ETHYL]QUINOXALINE'>4F7</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4yqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yqh OCA], [https://pdbe.org/4yqh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4yqh RCSB], [https://www.ebi.ac.uk/pdbsum/4yqh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4yqh ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/PDE10_HUMAN PDE10_HUMAN] Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate.<ref>PMID:17389385</ref>
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Authors: Burdi, D., Herman, L., Wang, T.
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==See Also==
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*[[Phosphodiesterase 3D structures|Phosphodiesterase 3D structures]]
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Description:
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== References ==
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[[Category: Unreleased Structures]]
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<references/>
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[[Category: Wang, T]]
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__TOC__
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[[Category: Herman, L]]
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</StructureSection>
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[[Category: Burdi, D]]
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Burdi D]]
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[[Category: Herman L]]
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[[Category: Wang T]]

Current revision

2-[2-(4-Phenyl-1H-imidazol-2-yl)ethyl]quinoxaline (Sunovion Compound 14) co-crystallized with PDE10A

PDB ID 4yqh

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