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2rce

From Proteopedia

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[[Image:2rce.jpg|left|200px]]
 
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{{Structure
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==DFP modified DegS delta PDZ==
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|PDB= 2rce |SIZE=350|CAPTION= <scene name='initialview01'>2rce</scene>, resolution 2.35&Aring;
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<StructureSection load='2rce' size='340' side='right'caption='[[2rce]], [[Resolution|resolution]] 2.35&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND=
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<table><tr><td colspan='2'>[[2rce]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RCE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RCE FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MIS:MONOISOPROPYLPHOSPHORYLSERINE'>MIS</scene></td></tr>
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|GENE= degS, hhoB, htrH ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 Escherichia coli])
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2qf0|2qf0]], [[2qf3|2qf3]], [[2qgr|2qgr]]</div></td></tr>
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}}
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">degS, hhoB, htrH ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rce FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rce OCA], [https://pdbe.org/2rce PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rce RCSB], [https://www.ebi.ac.uk/pdbsum/2rce PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rce ProSAT]</span></td></tr>
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'''DFP modified DegS delta PDZ'''
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</table>
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== Function ==
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[[https://www.uniprot.org/uniprot/DEGS_ECOLI DEGS_ECOLI]] When heat shock or other environmental stresses disrupt protein folding in the periplasm, DegS senses the accumulation of unassembled outer membrane porins (OMPs) and then initiates RseA (anti sigma-E factor) degradation by cleaving it in its periplasmic domain, making it an attractive substrate for subsequent cleavage by RseP. This cascade that ultimately leads to the sigma-E-driven expression of a variety of factors dealing with folding stress in the periplasm and OMP assembly.<ref>PMID:12183369</ref> <ref>PMID:19695325</ref>
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==About this Structure==
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== Evolutionary Conservation ==
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2RCE is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RCE OCA].
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Escherichia coli]]
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Check<jmol>
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[[Category: Single protein]]
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<jmolCheckbox>
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[[Category: Grant, R A.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rc/2rce_consurf.spt"</scriptWhenChecked>
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[[Category: Sauer, R T.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Sohn, J.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: dfp modified active site serine]]
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</jmolCheckbox>
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[[Category: hydrolase]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rce ConSurf].
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[[Category: periplasm]]
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<div style="clear:both"></div>
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[[Category: protease]]
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== References ==
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[[Category: serine protease]]
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<references/>
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__TOC__
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:34:42 2008''
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</StructureSection>
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[[Category: Bacillus coli migula 1895]]
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[[Category: Large Structures]]
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[[Category: Grant, R A]]
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[[Category: Sauer, R T]]
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[[Category: Sohn, J]]
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[[Category: Dfp modified active site serine]]
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[[Category: Hydrolase]]
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[[Category: Protease]]
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[[Category: Serine protease]]

Current revision

DFP modified DegS delta PDZ

PDB ID 2rce

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