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4tn4

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Current revision (00:08, 26 January 2017) (edit) (undo)
 
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==Crystal structure of ternary complex of Plasmodium vivax SHMT with glycine and a novel pyrazolopyran 33G: (4S)-6-amino-4-(5-cyano-3'-fluorobiphenyl-3-yl)-4-cyclobutyl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile==
==Crystal structure of ternary complex of Plasmodium vivax SHMT with glycine and a novel pyrazolopyran 33G: (4S)-6-amino-4-(5-cyano-3'-fluorobiphenyl-3-yl)-4-cyclobutyl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile==
<StructureSection load='4tn4' size='340' side='right' caption='[[4tn4]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
<StructureSection load='4tn4' size='340' side='right' caption='[[4tn4]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=33G:(4S)-6-AMINO-4-(5-CYANO-3-FLUOROBIPHENYL-3-YL)-4-CYCLOBUTYL-3-METHYL-2,4-DIHYDROPYRANO[2,3-C]PYRAZOLE-5-CARBONITRILE'>33G</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PLG:N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE]'>PLG</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=33G:(4S)-6-AMINO-4-(5-CYANO-3-FLUOROBIPHENYL-3-YL)-4-CYCLOBUTYL-3-METHYL-2,4-DIHYDROPYRANO[2,3-C]PYRAZOLE-5-CARBONITRILE'>33G</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PLG:N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE]'>PLG</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pff|4pff]], [[4pfn|4pfn]], [[4oyt|4oyt]], [[4o6z|4o6z]], [[4tmr|4tmr]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pff|4pff]], [[4pfn|4pfn]], [[4oyt|4oyt]], [[4o6z|4o6z]], [[4tmr|4tmr]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tn4 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tn4 RCSB], [http://www.ebi.ac.uk/pdbsum/4tn4 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tn4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tn4 OCA], [http://pdbe.org/4tn4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4tn4 RCSB], [http://www.ebi.ac.uk/pdbsum/4tn4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4tn4 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4tn4" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Serine hydroxymethyltransferase|Serine hydroxymethyltransferase]]
== References ==
== References ==
<references/>
<references/>

Current revision

Crystal structure of ternary complex of Plasmodium vivax SHMT with glycine and a novel pyrazolopyran 33G: (4S)-6-amino-4-(5-cyano-3'-fluorobiphenyl-3-yl)-4-cyclobutyl-3-methyl-2,4-dihydropyrano[2,3-c]pyrazole-5-carbonitrile

4tn4, resolution 2.20Å

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