2rck

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[[Image:2rck.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of juvenile hormone binding protein from Galleria mellonella hemolymph==
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|PDB= 2rck |SIZE=350|CAPTION= <scene name='initialview01'>2rck</scene>, resolution 2.44&Aring;
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<StructureSection load='2rck' size='340' side='right'caption='[[2rck]], [[Resolution|resolution]] 2.44&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Nag+Binding+Site+For+Residue+A+222'>AC1</scene>, <scene name='pdbsite=AC2:Nag+Binding+Site+For+Residue+B+222'>AC2</scene>, <scene name='pdbsite=AC3:So4+Binding+Site+For+Residue+A+223'>AC3</scene>, <scene name='pdbsite=AC4:So4+Binding+Site+For+Residue+B+223'>AC4</scene>, <scene name='pdbsite=AC5:Gol+Binding+Site+For+Residue+A+224'>AC5</scene> and <scene name='pdbsite=AC6:Gol+Binding+Site+For+Residue+B+224'>AC6</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> and <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>
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<table><tr><td colspan='2'>[[2rck]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Galleria_mellonella Galleria mellonella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RCK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RCK FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.44&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rck FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rck OCA], [https://pdbe.org/2rck PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rck RCSB], [https://www.ebi.ac.uk/pdbsum/2rck PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rck ProSAT]</span></td></tr>
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</table>
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'''Crystal structure of juvenile hormone binding protein from Galleria mellonella hemolymph'''
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== Function ==
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[https://www.uniprot.org/uniprot/Q8ITP4_GALME Q8ITP4_GALME]
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== Evolutionary Conservation ==
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==Overview==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rc/2rck_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rck ConSurf].
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<div style="clear:both"></div>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
Low molecular weight juvenile hormone binding proteins (JHBPs) are specific carriers of juvenile hormone (JH) in the hemolymph of butterflies and moths. As hormonal signal transmitters, these proteins exert a profound effect on insect development. The crystal structure of JHBP from Galleria mellonella shows an unusual fold consisting of a long alpha-helix wrapped in a highly curved antiparallel beta-sheet. JHBP structurally resembles the folding pattern found in tandem repeats in some mammalian lipid-binding proteins, with similar organization of one cavity and a disulfide bond between the long helix and the beta-sheet. JHBP reveals, therefore, an archetypal fold used by nature for hydrophobic ligand binding. The JHBP molecule possesses two hydrophobic cavities. Several lines of experimental evidence conclusively indicate that JHBP binds JH in only one cavity, close to the N- and C-termini, and that this binding induces a structural change. The second cavity, located at the opposite end of the molecule, could bind another ligand.
Low molecular weight juvenile hormone binding proteins (JHBPs) are specific carriers of juvenile hormone (JH) in the hemolymph of butterflies and moths. As hormonal signal transmitters, these proteins exert a profound effect on insect development. The crystal structure of JHBP from Galleria mellonella shows an unusual fold consisting of a long alpha-helix wrapped in a highly curved antiparallel beta-sheet. JHBP structurally resembles the folding pattern found in tandem repeats in some mammalian lipid-binding proteins, with similar organization of one cavity and a disulfide bond between the long helix and the beta-sheet. JHBP reveals, therefore, an archetypal fold used by nature for hydrophobic ligand binding. The JHBP molecule possesses two hydrophobic cavities. Several lines of experimental evidence conclusively indicate that JHBP binds JH in only one cavity, close to the N- and C-termini, and that this binding induces a structural change. The second cavity, located at the opposite end of the molecule, could bind another ligand.
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==About this Structure==
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Insect juvenile hormone binding protein shows ancestral fold present in human lipid-binding proteins.,Kolodziejczyk R, Bujacz G, Jakob M, Ozyhar A, Jaskolski M, Kochman M J Mol Biol. 2008 Mar 28;377(3):870-81. Epub 2008 Jan 16. PMID:18291417<ref>PMID:18291417</ref>
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2RCK is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Galleria_mellonella Galleria mellonella]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RCK OCA].
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==Reference==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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Insect Juvenile Hormone Binding Protein Shows Ancestral Fold Present in Human Lipid-Binding Proteins., Kolodziejczyk R, Bujacz G, Jakob M, Ozyhar A, Jaskolski M, Kochman M, J Mol Biol. 2008 Jan 16;. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18291417 18291417]
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</div>
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<div class="pdbe-citations 2rck" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
[[Category: Galleria mellonella]]
[[Category: Galleria mellonella]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Bujacz, G.]]
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[[Category: Bujacz G]]
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[[Category: Jakob, M.]]
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[[Category: Jakob M]]
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[[Category: Jaskolski, M.]]
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[[Category: Jaskolski M]]
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[[Category: Kochman, M.]]
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[[Category: Kochman M]]
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[[Category: Kolodziejczyk, R.]]
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[[Category: Kolodziejczyk R]]
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[[Category: Ozyhar, A.]]
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[[Category: Ozyhar A]]
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[[Category: GOL]]
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[[Category: NAG]]
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[[Category: SO4]]
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[[Category: galleria mellonella]]
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[[Category: hemolymph]]
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[[Category: hormone binding protein]]
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[[Category: jhbp-fold]]
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[[Category: juvenile hormone]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:34:50 2008''
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Current revision

Crystal structure of juvenile hormone binding protein from Galleria mellonella hemolymph

PDB ID 2rck

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