2xab

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==Structure of HSP90 with an inhibitor bound==
==Structure of HSP90 with an inhibitor bound==
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<StructureSection load='2xab' size='340' side='right' caption='[[2xab]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
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<StructureSection load='2xab' size='340' side='right'caption='[[2xab]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[2xab]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XAB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XAB FirstGlance]. <br>
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<table><tr><td colspan='2'>[[2xab]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XAB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2XAB FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=VHD:4-(1,3-DIHYDRO-2H-ISOINDOL-2-YLCARBONYL)-6-(1-METHYLETHYL)BENZENE-1,3-DIOL'>VHD</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2cdd|2cdd]], [[1yes|1yes]], [[1uy9|1uy9]], [[1byq|1byq]], [[2bsm|2bsm]], [[1osf|1osf]], [[2wi3|2wi3]], [[1uy8|1uy8]], [[2bug|2bug]], [[2wi4|2wi4]], [[2uwd|2uwd]], [[2wi7|2wi7]], [[2bt0|2bt0]], [[1yer|1yer]], [[1uyg|1uyg]], [[2bz5|2bz5]], [[2ccu|2ccu]], [[2ccs|2ccs]], [[1uyi|1uyi]], [[1yc3|1yc3]], [[1uyf|1uyf]], [[1uyd|1uyd]], [[2byi|2byi]], [[2wi2|2wi2]], [[1uy6|1uy6]], [[2vci|2vci]], [[2wi1|2wi1]], [[2vcj|2vcj]], [[1yc4|1yc4]], [[2fwz|2fwz]], [[2c2l|2c2l]], [[1uyk|1uyk]], [[1uyh|1uyh]], [[2cct|2cct]], [[2fwy|2fwy]], [[1uye|1uye]], [[1uyl|1uyl]], [[2wi6|2wi6]], [[1yc1|1yc1]], [[1uyc|1uyc]], [[1uy7|1uy7]], [[1yet|1yet]], [[2jjc|2jjc]], [[2byh|2byh]], [[2wi5|2wi5]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=VHD:4-(1,3-DIHYDRO-2H-ISOINDOL-2-YLCARBONYL)-6-(1-METHYLETHYL)BENZENE-1,3-DIOL'>VHD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xab OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xab RCSB], [http://www.ebi.ac.uk/pdbsum/2xab PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2xab FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xab OCA], [https://pdbe.org/2xab PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2xab RCSB], [https://www.ebi.ac.uk/pdbsum/2xab PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2xab ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN]] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
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[https://www.uniprot.org/uniprot/HS90A_HUMAN HS90A_HUMAN] Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.<ref>PMID:15937123</ref> <ref>PMID:11274138</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
<jmolCheckbox>
<jmolCheckbox>
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<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xa/2xab_consurf.spt"</scriptWhenChecked>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xa/2xab_consurf.spt"</scriptWhenChecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2xab ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 2xab" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==
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*[[Heat Shock Proteins|Heat Shock Proteins]]
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*[[Heat Shock Protein structures|Heat Shock Protein structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Human]]
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[[Category: Homo sapiens]]
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[[Category: Brian, M A.O]]
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[[Category: Large Structures]]
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[[Category: Callaghan, O]]
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[[Category: Callaghan O]]
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[[Category: Carr, M G]]
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[[Category: Carr MG]]
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[[Category: Chessari, G]]
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[[Category: Chessari G]]
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[[Category: Congreve, m]]
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[[Category: Congreve m]]
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[[Category: Cowan, S]]
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[[Category: Cowan S]]
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[[Category: Coyle, J E]]
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[[Category: Coyle JE]]
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[[Category: Downham, R]]
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[[Category: Downham R]]
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[[Category: Figueroa, E]]
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[[Category: Figueroa E]]
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[[Category: Frederickson, M]]
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[[Category: Frederickson M]]
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[[Category: Graham, B]]
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[[Category: Graham B]]
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[[Category: McMenamin, R]]
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[[Category: McMenamin R]]
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[[Category: Murray, C W]]
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[[Category: Murray CW]]
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[[Category: Patel, S]]
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[[Category: O'Brian MA]]
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[[Category: Phillips, T R]]
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[[Category: Patel S]]
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[[Category: Williams, G]]
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[[Category: Phillips TR]]
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[[Category: Woodhead, A J]]
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[[Category: Williams G]]
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[[Category: Woolford, A J.A]]
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[[Category: Woodhead AJ]]
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[[Category: Atp-binding]]
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[[Category: Woolford AJA]]
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[[Category: Cancer]]
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[[Category: Chaperone]]
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[[Category: Nucleotide-binding]]
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[[Category: Stress response]]
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Current revision

Structure of HSP90 with an inhibitor bound

PDB ID 2xab

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Proteopedia Page Contributors and Editors (what is this?)

OCA

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