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2rct

From Proteopedia

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[[Image:2rct.jpg|left|200px]]
 
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{{Structure
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==Crystal structure of human holo cellular retinol-binding protein II (CRBP-II)==
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|PDB= 2rct |SIZE=350|CAPTION= <scene name='initialview01'>2rct</scene>, resolution 1.20&Aring;
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<StructureSection load='2rct' size='340' side='right'caption='[[2rct]], [[Resolution|resolution]] 1.20&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Residue+A+151'>AC1</scene>, <scene name='pdbsite=AC2:So4+Binding+Site+For+Residue+A+152'>AC2</scene>, <scene name='pdbsite=AC3:Rtl+Binding+Site+For+Residue+A+140'>AC3</scene> and <scene name='pdbsite=AC4:Tla+Binding+Site+For+Residue+A+150'>AC4</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=RTL:RETINOL'>RTL</scene> and <scene name='pdbligand=TLA:L(+)-TARTARIC ACID'>TLA</scene>
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<table><tr><td colspan='2'>[[2rct]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RCT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RCT FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.2&#8491;</td></tr>
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|GENE= RBP2, CRBP2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=RTL:RETINOL'>RTL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=TLA:L(+)-TARTARIC+ACID'>TLA</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rct OCA], [https://pdbe.org/2rct PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rct RCSB], [https://www.ebi.ac.uk/pdbsum/2rct PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rct ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/RET2_HUMAN RET2_HUMAN] Intracellular transport of retinol.
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rc/2rct_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rct ConSurf].
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<div style="clear:both"></div>
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'''Crystal structure of human holo cellular retinol-binding protein II (CRBP-II)'''
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==See Also==
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*[[Retinol-binding protein|Retinol-binding protein]]
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*[[Retinol-binding protein 3D structures|Retinol-binding protein 3D structures]]
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==About this Structure==
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__TOC__
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2RCT is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RCT OCA].
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</StructureSection>
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==Reference==
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Crystal structure of human cellular retinol-binding protein II to 1.2 A resolution., Tarter M, Capaldi S, Carrizo ME, Ambrosi E, Perduca M, Monaco HL, Proteins. 2008 Mar;70(4):1626-30. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18076076 18076076]
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[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Single protein]]
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[[Category: Large Structures]]
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[[Category: Capaldi, S.]]
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[[Category: Capaldi S]]
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[[Category: Monaco, H L.]]
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[[Category: Monaco HL]]
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[[Category: Perduca, M.]]
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[[Category: Perduca M]]
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[[Category: RTL]]
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[[Category: SO4]]
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[[Category: TLA]]
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[[Category: cellular retinol-binding protein ii]]
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[[Category: crbp ii]]
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[[Category: cytoplasm]]
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[[Category: lipid-binding protein]]
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[[Category: retinol]]
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[[Category: transport]]
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[[Category: vitamin some]]
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[[Category: x-ray structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:34:53 2008''
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Current revision

Crystal structure of human holo cellular retinol-binding protein II (CRBP-II)

PDB ID 2rct

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