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4tmr

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==Crystal structure of ternary complex of Plasmodium vivax SHMT with glycine and a novel pyrazolopyran 99S: methyl 5-{3-[(4S)-6-amino-5-cyano-3-methyl-4-(propan-2-yl)-2,4-dihydropyrano[2,3-c]pyrazol-4-yl]-5-cyanophenyl}thiophene-2-carboxylate .==
==Crystal structure of ternary complex of Plasmodium vivax SHMT with glycine and a novel pyrazolopyran 99S: methyl 5-{3-[(4S)-6-amino-5-cyano-3-methyl-4-(propan-2-yl)-2,4-dihydropyrano[2,3-c]pyrazol-4-yl]-5-cyanophenyl}thiophene-2-carboxylate .==
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<StructureSection load='4tmr' size='340' side='right' caption='[[4tmr]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
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<StructureSection load='4tmr' size='340' side='right'caption='[[4tmr]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4tmr]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TMR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TMR FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4tmr]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_vivax_Sal-1 Plasmodium vivax Sal-1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TMR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4TMR FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=99S:METHYL+5-{3-[(4S)-6-AMINO-5-CYANO-3-METHYL-4-(PROPAN-2-YL)-2,4-DIHYDROPYRANO[2,3-C]PYRAZOL-4-YL]-5-CYANOPHENYL}THIOPHENE-2-CARBOXYLATE'>99S</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PLG:N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE]'>PLG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.7&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4pff|4pff]], [[4pfn|4pfn]], [[4oyt|4oyt]], [[4o6z|4o6z]], [[4tn4|4tn4]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=99S:METHYL+5-{3-[(4S)-6-AMINO-5-CYANO-3-METHYL-4-(PROPAN-2-YL)-2,4-DIHYDROPYRANO[2,3-C]PYRAZOL-4-YL]-5-CYANOPHENYL}THIOPHENE-2-CARBOXYLATE'>99S</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=PLG:N-GLYCINE-[3-HYDROXY-2-METHYL-5-PHOSPHONOOXYMETHYL-PYRIDIN-4-YL-METHANE]'>PLG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4tmr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tmr OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4tmr RCSB], [http://www.ebi.ac.uk/pdbsum/4tmr PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4tmr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4tmr OCA], [https://pdbe.org/4tmr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4tmr RCSB], [https://www.ebi.ac.uk/pdbsum/4tmr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4tmr ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/A5K8L9_PLAVS A5K8L9_PLAVS]
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4tmr" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Chitnumsub, P]]
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[[Category: Large Structures]]
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[[Category: Jaruwat, A]]
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[[Category: Plasmodium vivax Sal-1]]
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[[Category: Leartsakulpanich, U]]
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[[Category: Chitnumsub P]]
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[[Category: Witschel, M C]]
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[[Category: Jaruwat A]]
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[[Category: Alpha and beta protein]]
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[[Category: Leartsakulpanich U]]
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[[Category: Inhibitor]]
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[[Category: Witschel MC]]
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[[Category: Methyltransferase activity]]
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[[Category: Transferase]]
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[[Category: Transferase-transferase inhibitor complex]]
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Current revision

Crystal structure of ternary complex of Plasmodium vivax SHMT with glycine and a novel pyrazolopyran 99S: methyl 5-{3-[(4S)-6-amino-5-cyano-3-methyl-4-(propan-2-yl)-2,4-dihydropyrano[2,3-c]pyrazol-4-yl]-5-cyanophenyl}thiophene-2-carboxylate .

PDB ID 4tmr

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