2n17
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==NMR structure of a Kazal-type serine protease inhibitor from the subterranean termite defense gland of Coptotermes formosanus Shiraki soldiers== | |
| + | <StructureSection load='2n17' size='340' side='right'caption='[[2n17]]' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[2n17]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Coptotermes_formosanus Coptotermes formosanus]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2m25 2m25]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N17 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2N17 FirstGlance]. <br> | ||
| + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2n17 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n17 OCA], [https://pdbe.org/2n17 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2n17 RCSB], [https://www.ebi.ac.uk/pdbsum/2n17 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2n17 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/V9GZ93_COPFO V9GZ93_COPFO] | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Coptotermes formosanus is an imported, subterranean termite species with the largest economic impact in the United States. The frontal glands of the soldier caste termites comprising one third of the body mass, contain a secretion expelled through a foramen in defense. The small molecule composition of the frontal gland secretion is well-characterized, but the proteins remain to be identified. Herein is reported the structure and function of one of several proteins found in the termite defense gland secretion. TFP4 is a 6.9 kDa, non-classical group 1 Kazal-type serine protease inhibitor with activity towards chymotrypsin and elastase, but not trypsin. The 3-dimensional solution structure of TFP4 was solved with nuclear magnetic resonance spectroscopy, and represents the first structure from the taxonomic family, Rhinotermitidae. Based on the structure of TFP4, the protease inhibitor active loop (Cys8 to Cys16) was identified. | ||
| - | + | A Kazal-Type Serine Protease Inhibitor from the Defense Gland Secretion of the Subterranean Termite Coptotermes formosanus Shiraki.,Negulescu H, Guo Y, Garner TP, Goodwin OY, Henderson G, Laine RA, Macnaughtan MA PLoS One. 2015 May 15;10(5):e0125376. doi: 10.1371/journal.pone.0125376., eCollection 2015. PMID:25978745<ref>PMID:25978745</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| - | [[Category: | + | <div class="pdbe-citations 2n17" style="background-color:#fffaf0;"></div> |
| - | [[Category: | + | == References == |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Macnaughtan | + | [[Category: Coptotermes formosanus]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| + | [[Category: Garner TP]] | ||
| + | [[Category: Goodwin OY]] | ||
| + | [[Category: Guo Y]] | ||
| + | [[Category: Henderson G]] | ||
| + | [[Category: Laine RA]] | ||
| + | [[Category: Macnaughtan MA]] | ||
| + | [[Category: Negulescu H]] | ||
Current revision
NMR structure of a Kazal-type serine protease inhibitor from the subterranean termite defense gland of Coptotermes formosanus Shiraki soldiers
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