2rf3

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[[Image:2rf3.jpg|left|200px]]
 
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{{Structure
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==Crystal Structure of Tricyclo-DNA: An Unusual Compensatory Change of Two Adjacent Backbone Torsion Angles==
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|PDB= 2rf3 |SIZE=350|CAPTION= <scene name='initialview01'>2rf3</scene>, resolution 1.75&Aring;
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<StructureSection load='2rf3' size='340' side='right'caption='[[2rf3]], [[Resolution|resolution]] 1.75&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Zn+Binding+Site+For+Residue+B+308'>AC1</scene> and <scene name='pdbsite=AC2:Spm+Binding+Site+For+Residue+B+309'>AC2</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=SPM:SPERMINE'>SPM</scene>
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<table><tr><td colspan='2'>[[2rf3]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RF3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RF3 FirstGlance]. <br>
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|ACTIVITY=
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SPM:SPERMINE'>SPM</scene>, <scene name='pdbligand=TCY:(2R,3AS,4AR,5AR,5BS)-2-(6-AMINO-9H-PURIN-9-YL)-3A-HYDROXYHEXAHYDROCYCLOPROPA[4,5]CYCLOPENTA[1,2-B]FURAN-5A(4H)-YL+DIHYDROGEN+PHOSPHATE'>TCY</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rf3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rf3 OCA], [https://pdbe.org/2rf3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rf3 RCSB], [https://www.ebi.ac.uk/pdbsum/2rf3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rf3 ProSAT]</span></td></tr>
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</table>
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'''Crystal Structure of Tricyclo-DNA: An Unusual Compensatory Change of Two Adjacent Backbone Torsion Angles'''
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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==Overview==
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The crystal structure of a DNA duplex with tricyclo-DNA (tc-DNA) residues explains the increased RNA affinity of tc-DNA relative to DNA and tc-DNA's superior resistance to nucleases.
The crystal structure of a DNA duplex with tricyclo-DNA (tc-DNA) residues explains the increased RNA affinity of tc-DNA relative to DNA and tc-DNA's superior resistance to nucleases.
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==About this Structure==
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Crystal structure of tricyclo-DNA: an unusual compensatory change of two adjacent backbone torsion angles.,Pallan PS, Ittig D, Heroux A, Wawrzak Z, Leumann CJ, Egli M Chem Commun (Camb). 2008 Feb 21;(7):883-5. Epub 2007 Dec 21. PMID:18253536<ref>PMID:18253536</ref>
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2RF3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RF3 OCA].
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==Reference==
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Crystal structure of tricyclo-DNA: an unusual compensatory change of two adjacent backbone torsion angles., Pallan PS, Ittig D, Heroux A, Wawrzak Z, Leumann CJ, Egli M, Chem Commun (Camb). 2008 Feb 21;(7):883-5. Epub 2007 Dec 21. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18253536 18253536]
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[[Category: Single protein]]
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[[Category: Egli, M.]]
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[[Category: Heroux, A.]]
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[[Category: Ittig, D.]]
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[[Category: Leumann, C J.]]
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[[Category: Pallan, P S.]]
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[[Category: Wawrzak, Z.]]
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[[Category: SPM]]
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[[Category: ZN]]
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[[Category: conformationally constrained dna analog]]
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[[Category: dna duplex]]
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[[Category: tricyclo-dna]]
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[[Category: x-ray crystal structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:35:28 2008''
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 2rf3" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
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[[Category: Egli M]]
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[[Category: Heroux A]]
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[[Category: Ittig D]]
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[[Category: Leumann CJ]]
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[[Category: Pallan PS]]
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[[Category: Wawrzak Z]]

Current revision

Crystal Structure of Tricyclo-DNA: An Unusual Compensatory Change of Two Adjacent Backbone Torsion Angles

PDB ID 2rf3

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