4ynr
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==DosS GAFA Domain Reduced CO Bound Crystal Structure== | |
| + | <StructureSection load='4ynr' size='340' side='right'caption='[[4ynr]], [[Resolution|resolution]] 1.92Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4ynr]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_CDC1551 Mycobacterium tuberculosis CDC1551]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YNR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4YNR FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.92Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4ynr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ynr OCA], [https://pdbe.org/4ynr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4ynr RCSB], [https://www.ebi.ac.uk/pdbsum/4ynr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4ynr ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/DEVS_MYCTO DEVS_MYCTO] Member of the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response. May act as a redox sensor (rather than a direct hypoxia sensor); the normal (aerobic growth) state is the Fe(3+) form, while the reduced (anaerobic growth) Fe(2+) form is probably active for phosphate transfer. It is probably reduced by flavin nucleotides such as FMN and FAD. May be the primary sensor for CO. Donates a phosphate group to DevR (DosR) (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[Response regulator 3D structure|Response regulator 3D structure]] | |
| - | + | __TOC__ | |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Madrona | + | [[Category: Large Structures]] |
| + | [[Category: Mycobacterium tuberculosis CDC1551]] | ||
| + | [[Category: Madrona Y]] | ||
Current revision
DosS GAFA Domain Reduced CO Bound Crystal Structure
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