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2rhq

From Proteopedia

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[[Image:2rhq.jpg|left|200px]]
 
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{{Structure
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==PheRS from Staphylococcus haemolyticus- rational protein engineering and inhibitor studies==
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|PDB= 2rhq |SIZE=350|CAPTION= <scene name='initialview01'>2rhq</scene>, resolution 2.200&Aring;
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<StructureSection load='2rhq' size='340' side='right'caption='[[2rhq]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
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|SITE=
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> and <scene name='pdbligand=GAX:1-{3-[(4-pyridin-2-ylpiperazin-1-yl)sulfonyl]phenyl}-3-(1,3-thiazol-2-yl)urea'>GAX</scene>
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<table><tr><td colspan='2'>[[2rhq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_haemolyticus Staphylococcus haemolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RHQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RHQ FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Phenylalanine--tRNA_ligase Phenylalanine--tRNA ligase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=6.1.1.20 6.1.1.20]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2&#8491;</td></tr>
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|GENE= pheS ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1283 Staphylococcus haemolyticus]), pheT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1283 Staphylococcus haemolyticus])
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GAX:1-{3-[(4-PYRIDIN-2-YLPIPERAZIN-1-YL)SULFONYL]PHENYL}-3-(1,3-THIAZOL-2-YL)UREA'>GAX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rhq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rhq OCA], [https://pdbe.org/2rhq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rhq RCSB], [https://www.ebi.ac.uk/pdbsum/2rhq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rhq ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/SYFA_STAHJ SYFA_STAHJ]
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/rh/2rhq_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rhq ConSurf].
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<div style="clear:both"></div>
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'''PheRS from Staphylococcus haemolyticus- rational protein engineering and inhibitor studies'''
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==See Also==
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*[[Aminoacyl tRNA synthetase 3D structures|Aminoacyl tRNA synthetase 3D structures]]
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__TOC__
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==About this Structure==
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</StructureSection>
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2RHQ is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Staphylococcus_haemolyticus Staphylococcus haemolyticus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RHQ OCA].
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[[Category: Large Structures]]
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[[Category: Phenylalanine--tRNA ligase]]
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[[Category: Protein complex]]
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[[Category: Staphylococcus haemolyticus]]
[[Category: Staphylococcus haemolyticus]]
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[[Category: Evdokimov, A G.]]
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[[Category: Evdokimov AG]]
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[[Category: Mekel, M.]]
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[[Category: Mekel M]]
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[[Category: GAX]]
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[[Category: ZN]]
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[[Category: aminoacyl-trna synthetase]]
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[[Category: atp-binding]]
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[[Category: cytoplasm]]
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[[Category: heterotetramer]]
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[[Category: ligase]]
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[[Category: magnesium]]
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[[Category: metal-binding]]
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[[Category: nucleotide-binding]]
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[[Category: phenylalanine]]
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[[Category: protein biosynthesis]]
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[[Category: rna-binding]]
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[[Category: trna]]
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[[Category: trna-binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:36:12 2008''
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Current revision

PheRS from Staphylococcus haemolyticus- rational protein engineering and inhibitor studies

PDB ID 2rhq

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