Ferritin

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<applet load='Pdb2jd7.pdb' size='400' frame='true' align='right' scene="Ferritin/Starting_ferritin_scene/1" caption="Crystal structure of Fe-soaked ferritin from the hyperthermophilic archael anaerobe ''Pyrococcus furiousus'', [[2jd7]]" />
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<StructureSection load='' size='400' side='right' caption="Crystal structure of Fe-soaked ferritin from the hyperthermophilic archael anaerobe ''Pyrococcus furiousus'' [[2jd7]]" scene='Ferritin/Starting_ferritin_scene/1'>
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[[Ferritin]] (FR) is an iron storage and release protein. It stores iron as microcrystals with phosphate and hydroxide ions. FR is composed of 24 subunits of heavy chain (FTH) and light chain (FTL).<br />
 
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* '''Bacterioferritin''' (BFR) structure is very similar to FR. It contains a binuclear iron center and haem. It stores iron as ferric oxide mineral in its hollow central cavity.<br />
 
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* '''Thioferritin''' (TFR) is a ferritin-related protein with 2 cysteine residues adjacent to the dimetal binding site.<br />
 
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* Another iron storing protein is the '''DNA-binding Protein of Starved cells''' (Dps) - a ferritin-like diiron carboxylate.<br />
 
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* '''MrgA''' – another iron storage protein - belongs to the Dps family.
 
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==3D Structures of Ferritin==
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== Function ==
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Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
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[[Ferritin]] (FR) is an iron storage and release protein. It stores iron as microcrystals with phosphate and hydroxide ions. FR is composed of 24 subunits of heavy chain (FTH) and light chain (FTL).<ref>PMID:20304033</ref> Amphibians have an additional middle subunit FR (FTM).<br />
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{{#tree:id=OrganizedByTopic|openlevels=0|
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* '''apo-ferritin''' (apo-FR) is a non-Fe-containing ferritin.<br />
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* '''Bacterioferritin''' (BFR) structure is very similar to FR. It contains a binuclear iron center and haem. It stores iron as ferric oxide mineral in its hollow central cavity<ref>PMID:37375226</ref>.<br />
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* '''Thioferritin''' (TFR) is a ferritin-related protein with 2 cysteine residues adjacent to the dimetal binding site.<br />
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* '''DNA-binding Protein of Starved cells''' (Dps) - a ferritin-like diiron carboxylate which acts as a molecular chaperone and may confer thermotolerance in ''E. coli''<ref>PMID:37229826</ref>.<br />
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*Ferritin
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== Relevance ==
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**[[2jd6]], [[2jd7]] – PfFR - ''Pyrococcus furiosus'' <br />
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Cavities formed by FR are used for the manufacture of nanoparticles. FR is used as a marker for iron overload disorder.
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**[[2jd8]] – PfFR+Zn<br />
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**[[3kxu]] – hFR (mutant) – human<br />
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**[[3hx2]], [[3hx5]], [[3hx7]], [[1fha]] - hFR<br />
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**[[3a68]] – soFR from gene SferH4 – soybean<br />
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**[[3a9q]] - soFR from gene SferH4 (mutant) <br />
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**[[3egm]], [[3bvf]], [[3bvi]], [[3bvk]], [[3bvl]] – HpFR – ''Heliobacter pylori''<br />
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**[[3e6s]] - PnFR – Pseudo-nitzschia<br />
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**[[1z4a]], [[1vlg]] – FR – ''Thermotoga maritime''<br />
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**[[1s3q]], [[1sq3]], [[3kx9]] – FR – ''Archaeoglubus fulgidus''<br />
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**[[1krq]] – FR – ''Campylobacter jejuni''<br />
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**[[1eum]] - EcFR – ''Escherichia coli''<br />
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**[[4reu]] – EcFR + Fe<br />
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**[[1qgh]] – LiFR - ''Listeria innocua''<br />
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**[[1mfr]], [[1bg7]], [[3ka3]], [[3ka4]], [[3rbc]], [[3re7]], [[3rgd]], [[4das]] – bFR - Bullfrog<br />
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**[[3ka6]], [[3ka8]], [[3ka9]] – bFR (mutant)+Co<br />
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**[[3se1]], [[3sh6]], [[3shx]] - bFR (mutant) + Mg<br />
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**[[3qz3]] - VcFR – ''Vibrio cholerae''<br / >
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**[[3vnx]] – FR – ''Ulva pertusa''<br />
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**[[4ism]], [[4isp]], [[4itt]], [[4itw]], [[4iwj]], [[4iwk]], [[4ixk]] – FR – ''Pseudo-nitschia multiseries''<br />
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**[[1z6o]] – FR – ''Trichoplusia ni''<br />
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**[[4cmy]] – FR + Fe – ''Chlorobaculum tepidum''<br />
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*Ferritin light chain (FTL)
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== Disease ==
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**[[1lb3]], [[1h96]] – mFTL – mouse<br />
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FR deficiency can lead to anemia.
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**[[1rcc]], [[1rcd]], [[1rci]] – bFTL+tartrate+Mg<br />
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**[[1rce]], [[1rcg]] - bFTL+tartrate+Mn<br />
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**[[3noz]], [[3np0]], [[3np2]], [[3o7r]] – hoFTL (mutant) - horse<br />
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**[[3o7s]], [[3u90]] - hoFTL<br />
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**[[4v1w]] – hoFTL – cryo EM<br />
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**[[3rav]], [[3rd0]] – hoFTL + barbiturate
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*Ferritin heavy chain (FTH)
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==3D Structures of Ferritin==
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[[Ferritin 3D structures]]
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**[[2z6m]], [[1r03]], [[2fha]], [[3ajo]] – hFTH<br />
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**[[3ajp]], [[3ajq]], [[4dyx]], [[4dyy]], [[4dyz]], [[4dz0]] - hFTH (mutant)<br />
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**[[3wnw]] – mFTH<br />
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*Ferritin middle subunit (FTM)
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**[[4lpj]], [[4lqj]], [[4lqn]], [[4lqv]], [[4lyu]], [[4lyx]], [[4my7]] – bFTM + Fe – bullfrog<br />
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**[[4lpm]], [[4mku]] – bFTM (mutant) + Mg<br />
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**[[4lpn]] – bFTM (mutant) + Co<br />
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**[[4mjy]], [[4ml5]], [[4mn9]] – bFTM (mutant) + Fe<br />
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**[[4p18]] – bFTM (mutant) <br />
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**[[4lqh]] – bFTM + Mg<br />
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*apo-ferritin (apo-FR)
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**[[2x17]] – apo-PfFR+Ag <br />
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**[[3h7g]] – apo-hoFR+Au <br />
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**[[1hrs]] - apo-hoFR+protoporphyrin<br />
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**[[3bve]] – apo-HpFR<br />
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**[[3e6r]] – apo-PnFR <br />
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**[[2clu]], [[2cn6]] - apo-hFR (mutant)+Zn<br />
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*apo-ferritin light chain (apo-FTL)
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**[[2zg7]], [[2z5p]], [[2z5q]], [[2z5r]], [[3fi6]], [[3af7]] – apo-hoFTL+Pd<br />
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**[[2zg8]], [[2zg9]], [[3af8]], [[3af9]] - apo-hoFTL (mutant)+Pd<br />
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**[[3f33]], [[3f34]], [[3f35]], [[3f36]], [[3f37]], [[3f38]], [[3f39]] - apo-hoFTL+phenols<br />
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**[[2v2i]], [[2v2j]] - apo-hoFTL+haemin<br />
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**[[2gyd]] - apo-hoFTL+diaziflurane<br />
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**[[1xz1]] - apo-hoFTL+halothane<br />
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**[[1xz3]] - apo-hoFTL+isoflurane<br />
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**[[1gwg]] - apo-hoFTL+I3<br />
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**[[2v2l]], [[2v2m]], [[2v2n]], [[2v2o]], [[2v2p]], [[2v2r]], [[2v2s]] - apo-hoFTL (mutant)+haemin<br />
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**[[2za6]], [[2g4h]], [[1aew]], [[1dat]], [[1ier]], [[1ies]], [[3f32]], [[2zur]], [[2w0o]] - apo-hoFTL<br />
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**[[2ffx]], [[2fg4]], [[2fg8]] – apo-hFTL<br />
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**[[4de6]] - apo-hoFTL + arachidonic acid
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*apo-ferritin heavy chain (apo-FTH)
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**[[2za7]], [[2za8]], [[2cn7]], [[2chi]], [[2clu]] - apo-hoFTH (mutant) <br />
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**[[2cei]], [[2cih]], [[2cn6]], [[2iu2]] - apo-hoFTH (mutant)+Zn<br />
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**[[3erz]] – apo-hFR+Hg<br />
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**[[3es3]] - apo-hFR+Au<br />
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*Bacterioferritin (BFR)
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**[[3gvy]] – BFR – ''Rhodobacter sphaeroides''<br />
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**[[1jgc]] - BFR – ''Rhodobacter capsulatus''<br />
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**[[1ji4]] – BFR – ''Helicobacter pylori''<br />
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**[[1nf4]], [[1nf6]], [[1nfv]] – BFR – ''Desulfovibrio desulfuricans''<br />
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**[[3fvb]] – BmBFR - ''Brucelia melitensis''<br />
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**[[2fkz]], [[2fl0]], [[1sof]] – BFR – ''Azotobacrter vinelandii''<br />
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**[[2wtl]], [[3qb9]], [[3uof]], [[3uoi]] – BFR – ''Mycobacterium tuberculosis''<br />
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**[[3bkn]] - MsBFR – ''Mycobacterium smegmatis''<br />
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**[[3is7]], [[3is8]], [[3ise]], [[3isf]], [[3r2h]], [[3r2k]], [[3r2l]], [[3r2m]], [[3r2o]], [[3r2r]], [[3r2s]] – BFR – ''Pseudomonas aeruginosa''<br />
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**[[1bfr]], [[1bcf]], [[2htn]], [[2vxi]], [[3e1j]], [[3e1l]], [[3e1m]], [[3e1n]], [[3e1p]], [[3e1o]], [[3e1q]], [[2y3q]] – EcBFR <br />
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**[[3e2c]], [[4cvr]], [[4cvt]] – EcBFR (mutant) + Zn<br />
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**[[4cvp]], [[3ghq]] - EcBFR (mutant) + Fe<br />
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**[[4cvs]] – EcBFR (mutant) + Cd<br />
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**[[4am2]], [[4am4]], [[4am5]] – BFR + Fe – ''Blastochloris viridis''
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*Thioferritin (TFR)
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**[[2vzb]] – TFR – ''Bacterioides fragilis''
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*DNA-binding Protein of Starved cells (Dps)
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</StructureSection>
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**[[3iq1]] – VcDps <br />
 
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**[[3ge4]] – BmDps <br />
 
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**[[2iy4]] – Dps + Fe – ''Listeria monocytogenes''<br />
 
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**[[2bkc]], [[2bk6]], [[2bjy]] – LiDps (mutant) <br />
 
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**[[2f7n]] – Dps + Co – ''Deinococcus radiodurans''<br />
 
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**[[4a25]] - Dps + Mn – ''Kinecoccus radiodurans''<br />
 
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**[[1tjo]], [[1tk6]], [[1tkp]], [[1tko]], [[1moj]] – Dps + Fe – ''Halobacterium salinarum''<br />
 
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**[[1o9r]] – Dps + Fe – ''Agrobacterium tumefaciens''<br />
 
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**[[1dps]], [[1f33]] – EcDps <br />
 
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**[[1f30]] – EcDps + Zn<br />
 
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**[[1jre]] – EcDps + Cd<br />
 
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**[[1jts]], [[1l8h]], [[1l8i]] – EcDps (mutant)<br />
 
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**[[2ux1]] – SsDps + Zn – ''Streptococcus suis''<br />
 
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**[[2v15]] – SsDps + Te<br />
 
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**[[2xjm]] – SsDps + Co<br />
 
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**[[2xjn]] – SsDps + Cu<br />
 
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**[[2xjo]] – SsDps + Ni<br />
 
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**[[2xkq]] – SsDps + Mn<br />
 
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**[[2yw6]], [[2yw7]] – MsDps<br />
 
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**[[3ak8]], [[3ak9]] – Dps + Mg – ''Salmonella enterica''<br />
 
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**[[1n1q]] – Dps + Fe2O– ''Brevibacillus brevis''<br />
 
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**[[1vei]], [[1vel]], [[1veq]] – MsDps + Fe <br />
 
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**[[4dyu]] – Dpo + Zn – ''Yersinia pestis''
 
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*MrgA
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== References ==
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<references/>
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**[[2chp]] – MrgA – ''Bacillus subtilis''<br />
 
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}}
 
[[Category:Topic Page]]
[[Category:Topic Page]]

Current revision

Crystal structure of Fe-soaked ferritin from the hyperthermophilic archael anaerobe Pyrococcus furiousus 2jd7

Drag the structure with the mouse to rotate


References

  1. ↑ Wang W, Knovich MA, Coffman LG, Torti FM, Torti SV. Serum ferritin: Past, present and future. Biochim Biophys Acta. 2010 Aug;1800(8):760-9. doi: 10.1016/j.bbagen.2010.03.011. , Epub 2010 Mar 19. PMID:20304033 doi:http://dx.doi.org/10.1016/j.bbagen.2010.03.011
  2. ↑ van der Ven AM, Gyamfi H, Suttisansanee U, Ahmad MS, Su Z, Taylor RM, Poole A, Chiorean S, Daub E, Urquhart T, Honek JF. Molecular Engineering of E. coli Bacterioferritin: A Versatile Nanodimensional Protein Cage. Molecules. 2023 Jun 9;28(12):4663. PMID:37375226 doi:10.3390/molecules28124663
  3. ↑ Park JH, Lee ES, Jung YJ. Functional characterization of the DNA-binding protein from starved cells (DPS) as a molecular chaperone under heat stress. Biochem Biophys Res Commun. 2023 Jul 30;667:180-185. PMID:37229826 doi:10.1016/j.bbrc.2023.05.064

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