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Ficolin

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Current revision (11:03, 19 March 2019) (edit) (undo)
 
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{{STRUCTURE_2j64| PDB=2j64 | SIZE=400| SCENE= |right|CAPTION=Human H-ficolin binding domain trimer complex with Ca+2 ion, [[2j64]] }}
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<StructureSection load='2j64' size='350' side='right' scene='46/466464/Cv/1' caption='Human H-ficolin binding domain trimer complex with Ca+2 ion (PDB code [[2j64]]) '>
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'''Ficolin''' (Fic) are defense proteins which belong to the innate immune system and recognize carbohydrate molecules. 3 ficolins were identified in humans L-Fic, H-Fic and M-Fic.
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== Function ==
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'''Ficolin''' (Fic) are defense proteins which belong to the innate immune system and recognize carbohydrate molecules<ref>PMID:9777405</ref>. 3 ficolins were identified in humans '''L-Fic''' or '''ficolin-2''', '''H-Fic''' or '''ficolin-3''' and '''M-Fic''' or '''ficolin-1'''.
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== Disease ==
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Fn may play a role in inflammatory diseases, apoptosis, lupus, preeclampsia and IgA nephropathy<ref>PMID:19025118</ref>.
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== Structural highlights ==
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<scene name='46/466464/Cv/4'>Human H-ficolin binding domain trimer</scene>.
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<scene name='46/466464/Cv/5'>Ca coordination site</scene> (PDB code [[2j64]]).<ref>PMID:17215869</ref> Water molecules shown as red spheres.
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</StructureSection>
== 3D Structures of Ficolin ==
== 3D Structures of Ficolin ==
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== References ==
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<references/>

Current revision

Human H-ficolin binding domain trimer complex with Ca+2 ion (PDB code 2j64)

Drag the structure with the mouse to rotate

3D Structures of Ficolin

Updated on 19-March-2019


References

  1. ↑ Lu J, Le Y. Ficolins and the fibrinogen-like domain. Immunobiology. 1998 Aug;199(2):190-9. PMID:9777405 doi:http://dx.doi.org/10.1016/S0171-2985(98)80026-0
  2. ↑ Zhang XL, Ali MA. Ficolins: structure, function and associated diseases. Adv Exp Med Biol. 2008;632:105-15. PMID:19025118
  3. ↑ Garlatti V, Belloy N, Martin L, Lacroix M, Matsushita M, Endo Y, Fujita T, Fontecilla-Camps JC, Arlaud GJ, Thielens NM, Gaboriaud C. Structural insights into the innate immune recognition specificities of L- and H-ficolins. EMBO J. 2007 Jan 24;26(2):623-33. Epub 2007 Jan 11. PMID:17215869

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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