2v90

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[[Image:2v90.gif|left|200px]]<br />
 
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<applet load="2v90" size="450" color="white" frame="true" align="right" spinBox="true"
 
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caption="2v90, resolution 2.00&Aring;" />
 
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'''CRYSTAL STRUCTURE OF THE 3RD PDZ DOMAIN OF INTESTINE- AND KIDNEY-ENRICHED PDZ DOMAIN IKEPP (PDZD3)'''<br />
 
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==About this Structure==
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==Crystal structure of the 3rd PDZ domain of intestine- and kidney- enriched PDZ domain IKEPP (PDZD3)==
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2V90 is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with SO4 as [http://en.wikipedia.org/wiki/ligand ligand]. Structure known Active Site: AC1. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2V90 OCA].
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<StructureSection load='2v90' size='340' side='right'caption='[[2v90]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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[[Category: Homo sapiens]]
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== Structural highlights ==
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[[Category: Single protein]]
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<table><tr><td colspan='2'>[[2v90]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2V90 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2V90 FirstGlance]. <br>
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[[Category: Arrowsmith, C.H.]]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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[[Category: Bunkoczi, G.]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Cooper, C.]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2v90 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2v90 OCA], [https://pdbe.org/2v90 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2v90 RCSB], [https://www.ebi.ac.uk/pdbsum/2v90 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2v90 ProSAT]</span></td></tr>
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[[Category: Doyle, D.A.]]
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</table>
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[[Category: Edwards, A.]]
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== Function ==
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[[Category: Elkins, J.]]
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[https://www.uniprot.org/uniprot/NHRF4_HUMAN NHRF4_HUMAN] Acts as a regulatory protein that associates with GUCY2C and negatively modulates its heat-stable enterotoxin-mediated activation (PubMed:11950846). Stimulates SLC9A3 activity in the presence of elevated calcium ions (PubMed:19088451).<ref>PMID:11950846</ref> <ref>PMID:19088451</ref>
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[[Category: Gileadi, C.]]
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== Evolutionary Conservation ==
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[[Category: Phillips, C.]]
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[[Image:Consurf_key_small.gif|200px|right]]
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[[Category: Pike, A.C.W.]]
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Check<jmol>
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[[Category: Salah, E.]]
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<jmolCheckbox>
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[[Category: Sundstrom, M.]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/v9/2v90_consurf.spt"</scriptWhenChecked>
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[[Category: Ugochukwu, E.]]
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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[[Category: Uppenberg, J.]]
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<text>to colour the structure by Evolutionary Conservation</text>
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[[Category: Weigelt, J.]]
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</jmolCheckbox>
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[[Category: SO4]]
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2v90 ConSurf].
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[[Category: alternative splicing]]
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<div style="clear:both"></div>
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[[Category: cytoplasm]]
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[[Category: membrane]]
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[[Category: pdz domain]]
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[[Category: pdzd3]]
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[[Category: protein-binding]]
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''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 5 14:17:28 2007''
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==See Also==
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*[[Sodium-hydrogen exchange regulatory factor 3D structures|Sodium-hydrogen exchange regulatory factor 3D structures]]
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Arrowsmith CH]]
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[[Category: Bunkoczi G]]
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[[Category: Cooper C]]
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[[Category: Doyle DA]]
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[[Category: Edwards A]]
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[[Category: Elkins J]]
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[[Category: Gileadi C]]
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[[Category: Phillips C]]
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[[Category: Pike ACW]]
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[[Category: Salah E]]
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[[Category: Sundstrom M]]
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[[Category: Ugochukwu E]]
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[[Category: Uppenberg J]]
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[[Category: Weigelt J]]

Current revision

Crystal structure of the 3rd PDZ domain of intestine- and kidney- enriched PDZ domain IKEPP (PDZD3)

PDB ID 2v90

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