Sandbox Reserved 1074

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{{Sandbox_Reserved_Butler_CH462_Sp2015_#}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE -->
{{Sandbox_Reserved_Butler_CH462_Sp2015_#}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE -->
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==Your Protein Name here==
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<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
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This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
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=='''Enoyl-ACP Reductase InhA from ''Mycobacterium tuberculosis'''''==
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== Biological Function ==
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<StructureSection load='4OHU' size='340' side='right' caption='Enoyl-ACP Reductase InhA Homotetramer'>
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== Structural Overview ==
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== '''Introduction''' ==
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== Mechanism of Action ==
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=== '''FAS-II System''' ===
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== Zinc Ligand(s) ==
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=== '''Mechanism of Action''' ===
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== Other Ligands ==
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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== '''Structure''' ==
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Crystal structures of InhA reveal a <scene name='69/694241/Homotetramer_subunits_labeled/1'>homotetramer</scene> with separate ligand binding sites in each subunit. Each <scene name='69/694241/Monomer_subunit_no_ligands/1'>monomer</scene> subunit features a single domain with a central core that supports a NADH binding site. The alpha6 and alpha7 helices of the monomer form one side of the fatty acyl substrate binding crevice of InhA. Within this binding crevice, many hydrophobic side chains from the amino acids involved in forming the substrate binding loop, <scene name='69/694241/Monomer_subunit_196_219/1'> residues 196-219</scene>, interact with the substrates. [[Image:Fatty Acyl Binding Crevice.jpg|thumb|200px|left|alt=Fatty Acyl Binding Crevice]] One side of this cavity is open and exposed to solvent, which allows the substrates to access the binding pocket of this enzyme. The size of the substrate binding loop is a primary determinant of the ability of InhA to distinguish between shorter and longer substrates and provide <scene name='69/694241/Substrate_binding_pocket/1'>specificity</scene> for the enoyl-ACP reductase reaction.
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=== '''Fatty Acyl Binding Crevice''' ===
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[[Image:Binding Pocket - Mesh.jpg|thumb|200px|right|Substrate Binding Pocket (NADH = green; fatty acyl substrate = red)]]
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<scene name='69/694241/Monomer_subunit/2'>NADH binding site</scene>.
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<scene name='69/697507/Fatty_acyl_binding_crevice/3'>Space-Filled Model of Atoms in Fatty Acyl Binding Crevice</scene>
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=== '''Catalytic Triad''' ===
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=== '''Hydrogen Bonding Interactions''' ===
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== '''Clinical Applications''' ==
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This is a sample scene created with SAT to <scene name="69/697507/Fatty_acyl_binding_crevice/3">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
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</StructureSection>
</StructureSection>
== References ==
== References ==
<references/>
<references/>

Current revision

This Sandbox is Reserved from 02/09/2015, through 05/31/2016 for use in the course "CH462: Biochemistry 2" taught by Geoffrey C. Hoops at the Butler University. This reservation includes Sandbox Reserved 1051 through Sandbox Reserved 1080.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

Your Protein Name here

Caption for this structure

Drag the structure with the mouse to rotate

References

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
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