4q6x

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==Structure of phospholipase D Beta1B1i from Sicarius terrosus venom at 2.14 A resolution==
==Structure of phospholipase D Beta1B1i from Sicarius terrosus venom at 2.14 A resolution==
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<StructureSection load='4q6x' size='340' side='right' caption='[[4q6x]], [[Resolution|resolution]] 2.14&Aring;' scene=''>
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<StructureSection load='4q6x' size='340' side='right'caption='[[4q6x]], [[Resolution|resolution]] 2.14&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4q6x]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q6X OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q6X FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4q6x]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sicarius_terrosus Sicarius terrosus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q6X OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Q6X FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.14&#8491;</td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lyase Lyase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.6.1.17 4.6.1.17] </span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q6x OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4q6x RCSB], [http://www.ebi.ac.uk/pdbsum/4q6x PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4q6x FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q6x OCA], [https://pdbe.org/4q6x PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4q6x RCSB], [https://www.ebi.ac.uk/pdbsum/4q6x PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4q6x ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/BIB11_SICTE BIB11_SICTE] Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate (PubMed:25752604). This toxin acts on lysophosphatidylethanolamine (LPE) and ceramide phosphoethanolamine (CPE) with high activity (PubMed:25752604). This toxin acts on sphingomyelin (SM) with very low activity and is not active on lysophosphatidylserine (LPS), lysophosphatidylcholine (LPC) and lysophosphatidylglycerol (LPG) (PubMed:25752604). It acts by transphosphatidylation, releasing exclusively cyclic phosphate as second products (PubMed:25752604). It is not surprising that spider toxins have affinity for ethanolamine-containing sphingolipids since they are common in insect prey (PubMed:25752604). Induces dermonecrosis, hemolysis, increased vascular permeability, edema, inflammatory response, and platelet aggregation (By similarity).[UniProtKB:P0CE80]<ref>PMID:25752604</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4q6x" style="background-color:#fffaf0;"></div>
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==See Also==
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*[[Phospholipase D 3D structures|Phospholipase D 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Lyase]]
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[[Category: Large Structures]]
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[[Category: Binford, G J]]
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[[Category: Sicarius terrosus]]
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[[Category: Cordes, M H]]
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[[Category: Binford GJ]]
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[[Category: Lajoie, D M]]
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[[Category: Cordes MH]]
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[[Category: Roberts, S A]]
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[[Category: Lajoie DM]]
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[[Category: Zobel-Thropp, P A]]
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[[Category: Roberts SA]]
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[[Category: Tim barrel]]
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[[Category: Zobel-Thropp PA]]
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[[Category: Venom gland secretion of sicarius terrosus]]
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Current revision

Structure of phospholipase D Beta1B1i from Sicarius terrosus venom at 2.14 A resolution

PDB ID 4q6x

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