4z4q
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Quinazolinedione(PD 0305970)-DNA cleavage complex of topoisomerase IV from S. pneumoniae== | |
| + | <StructureSection load='4z4q' size='340' side='right'caption='[[4z4q]], [[Resolution|resolution]] 3.04Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4z4q]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pneumoniae_TIGR4 Streptococcus pneumoniae TIGR4] and [https://en.wikipedia.org/wiki/PBR322_based_IG-lambda_expression_vector PBR322 based IG-lambda expression vector]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z4Q OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Z4Q FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.04Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PDQ:3-AMINO-7-{(3R)-3-[(1S)-1-AMINOETHYL]PYRROLIDIN-1-YL}-1-CYCLOPROPYL-6-FLUORO-8-METHYLQUINAZOLINE-2,4(1H,3H)-DIONE'>PDQ</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4z4q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z4q OCA], [https://pdbe.org/4z4q PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4z4q RCSB], [https://www.ebi.ac.uk/pdbsum/4z4q PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4z4q ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/PARC_STRPN PARC_STRPN] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.<ref>PMID:17375187</ref> <ref>PMID:20596531</ref> [https://www.uniprot.org/uniprot/PARE_STRPN PARE_STRPN] Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule.<ref>PMID:17375187</ref> <ref>PMID:20596531</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[Topoisomerase 3D structures|Topoisomerase 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: Laponogov | + | [[Category: Large Structures]] |
| - | [[Category: Pan | + | [[Category: PBR322 based IG-lambda expression vector]] |
| - | [[Category: Sanderson | + | [[Category: Streptococcus pneumoniae TIGR4]] |
| - | [[Category: | + | [[Category: Crevel IM-T]] |
| - | [[Category: | + | [[Category: Fisher LM]] |
| + | [[Category: Laponogov I]] | ||
| + | [[Category: Pan X-S]] | ||
| + | [[Category: Sanderson MR]] | ||
| + | [[Category: Selvarajah J]] | ||
| + | [[Category: Veselkov DA]] | ||
Current revision
Quinazolinedione(PD 0305970)-DNA cleavage complex of topoisomerase IV from S. pneumoniae
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