4cv9
From Proteopedia
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==MPS1 kinase with 3-aminopyridin-2-one inhibitors== | ==MPS1 kinase with 3-aminopyridin-2-one inhibitors== | ||
| - | <StructureSection load='4cv9' size='340' side='right' caption='[[4cv9]], [[Resolution|resolution]] 2.50Å' scene=''> | + | <StructureSection load='4cv9' size='340' side='right'caption='[[4cv9]], [[Resolution|resolution]] 2.50Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4cv9]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CV9 OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[4cv9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4CV9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4CV9 FirstGlance]. <br> |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=W2K:4-(4-METHYLPIPERAZIN-1-YL)-N-(2-OXO-5-(PYRIDIN-4-YL)-1,2-DIHYDROPYRIDIN-3-YL)BENZAMIDE'>W2K</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.5Å</td></tr> |
| - | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=TPO:PHOSPHOTHREONINE'>TPO</scene>, <scene name='pdbligand=W2K:4-(4-METHYLPIPERAZIN-1-YL)-N-(2-OXO-5-(PYRIDIN-4-YL)-1,2-DIHYDROPYRIDIN-3-YL)BENZAMIDE'>W2K</scene></td></tr> | |
| - | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4cv9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4cv9 OCA], [https://pdbe.org/4cv9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4cv9 RCSB], [https://www.ebi.ac.uk/pdbsum/4cv9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4cv9 ProSAT]</span></td></tr> | |
| - | + | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref> |
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| + | ==See Also== | ||
| + | *[[Dual specificity protein kinase 3D structures|Dual specificity protein kinase 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: Bavetsias | + | [[Category: Large Structures]] |
| - | [[Category: Bayliss | + | [[Category: Bavetsias V]] |
| - | [[Category: Fearon | + | [[Category: Bayliss R]] |
| - | [[Category: Jones | + | [[Category: Fearon D]] |
| - | [[Category: Schmitt | + | [[Category: Jones K]] |
| - | [[Category: Westwood | + | [[Category: Schmitt J]] |
| - | [[Category: VanMontfort | + | [[Category: Westwood IM]] |
| - | + | [[Category: VanMontfort RLM]] | |
| - | + | ||
Current revision
MPS1 kinase with 3-aminopyridin-2-one inhibitors
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