Sandbox Reserved 1073

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{{Sandbox_Reserved_Butler_CH462_Sp2015_#}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE -->
{{Sandbox_Reserved_Butler_CH462_Sp2015_#}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE -->
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==Enoyl-ACP Reductase InhA==
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==Your Protein Name here==
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<StructureSection load='4OHU' size='240' side='right' caption='Enoyl-ACP Reductase InhA Homotetramer' scene=''>
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<StructureSection load='1stp' size='340' side='right' caption='Caption for this structure' scene=''>
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This is a default text for your page ''''''. Click above on '''edit this page''' to modify. Be careful with the &lt; and &gt; signs.
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue.
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== Introduction ==
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== Biological Function ==
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The Enoyl-ACP Reductase InhA, from [http://en.wikipedia.org/wiki/Mycobacterium_tuberculosis ''Mycobacterium tuberculosis''], catalyzes the [http://en.wikipedia.org/wiki/Nicotinamide_adenine_dinucleotide NADH]-dependent reduction of long-chain ''trans''-2-enoyl-ACP fatty acids in the type II fatty acid biosynthesis pathway of ''M.'' ''tuberculosis''. InhA is a member of the [http://en.wikipedia.org/wiki/Short-chain_dehydrogenase short chain dehydrogenase/reductase] (SDR) family of enzymes. InhA is the only enoyl-ACP reductase found in tuberculosis, making the enzyme a potential drug target.
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== Structural Overview ==
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=== FAS-II System ===
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== Mechanism of Action ==
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[http://en.wikipedia.org/wiki/Mycolic_acid Mycolic acids] are very long-chain fatty acids (C<sub>60</sub> -C<sub>90</sub>) that are essential components of the mycobacterial cell wall. Mycolic acids are synthesized by at least two known elongation systems, type I and type II [http://en.wikipedia.org/wiki/Fatty_acid_synthase fatty acid synthases] (FAS-I and FAS-II). The FAS-II system prefers C16 as a starting substrate and can extend up to C56. The FAS-II system utilizes the products from the FAS-I system as primers to extend the chain lengths further. The products of the FAS-II system are the precursors of mycolic acids. Elongation by the FAS-II system occurs by a [http://en.wikipedia.org/wiki/Condensation_reaction condensation reaction], which is achieved in three steps. Step 1 involves transfer of the acyl primer, step 2 involves [http://en.wikipedia.org/wiki/Decarboxylation decarboxylation] of the substrate to yield a [http://en.wikipedia.org/wiki/Carbanion carbanion], and step 3 involves nucleophilic attack of the carbanion to yield the elongated product.
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== Zinc Ligand(s) ==
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=== Mechanism of Action ===
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== Other Ligands ==
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== Structure ==
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=== Fatty Acyl Binding Crevice ===
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=== Catalytic Triad ===
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=== Hydrogen Bonding Interactions ===
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== Clinical Applications ==
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=== Isoniazid ===
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=== Other Inhibitors ===
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.
This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes.

Current revision

This Sandbox is Reserved from 02/09/2015, through 05/31/2016 for use in the course "CH462: Biochemistry 2" taught by Geoffrey C. Hoops at the Butler University. This reservation includes Sandbox Reserved 1051 through Sandbox Reserved 1080.
To get started:
  • Click the edit this page tab at the top. Save the page after each step, then edit it again.
  • Click the 3D button (when editing, above the wikitext box) to insert Jmol.
  • show the Scene authoring tools, create a molecular scene, and save it. Copy the green link into the page.
  • Add a description of your scene. Use the buttons above the wikitext box for bold, italics, links, headlines, etc.

More help: Help:Editing

Your Protein Name here

Caption for this structure

Drag the structure with the mouse to rotate

References

  1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
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