4wqp

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==Crystal structure of RORc in complex with a benzyl sulfonamide inverse agonist==
==Crystal structure of RORc in complex with a benzyl sulfonamide inverse agonist==
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<StructureSection load='4wqp' size='340' side='right' caption='[[4wqp]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
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<StructureSection load='4wqp' size='340' side='right'caption='[[4wqp]], [[Resolution|resolution]] 1.99&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4wqp]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WQP OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WQP FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4wqp]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WQP OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4WQP FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3SX:N-[4-(4-ACETYLPIPERAZIN-1-YL)BENZYL]-N-(2-METHYLPROPYL)-1-PHENYLMETHANESULFONAMIDE'>3SX</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.99&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wqp OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4wqp RCSB], [http://www.ebi.ac.uk/pdbsum/4wqp PDBsum]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3SX:N-[4-(4-ACETYLPIPERAZIN-1-YL)BENZYL]-N-(2-METHYLPROPYL)-1-PHENYLMETHANESULFONAMIDE'>3SX</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4wqp FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wqp OCA], [https://pdbe.org/4wqp PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4wqp RCSB], [https://www.ebi.ac.uk/pdbsum/4wqp PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4wqp ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN]] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
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[https://www.uniprot.org/uniprot/RORG_HUMAN RORG_HUMAN] Possible nuclear receptor for hydroxycholesterols, the binding of which strongly promotes coactivators recruitment. Essential for thymopoiesis and the development of several secondary lymphoid tissues, including lymph nodes. Involved in lineage specification of uncommitted CD4(+) T-helper cells into Th17 cells. Regulate the expression of several components of the circadian clock.
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 4wqp" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Boenig, G]]
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[[Category: Homo sapiens]]
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[[Category: Hymowitz, S G]]
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[[Category: Large Structures]]
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[[Category: Nuclear receptor ligand binding domain]]
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[[Category: Boenig G]]
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[[Category: Transcription]]
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[[Category: Hymowitz SG]]

Current revision

Crystal structure of RORc in complex with a benzyl sulfonamide inverse agonist

PDB ID 4wqp

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