4z6y
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4z6y is ON HOLD Authors: Gai, Z., Wu, G. Description: Category: Unreleased Structures Category: Wu, G Category: Gai, Z) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of the TBC1D7-TSC1 complex== | |
| - | + | <StructureSection load='4z6y' size='340' side='right'caption='[[4z6y]], [[Resolution|resolution]] 2.81Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[4z6y]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Z6Y OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4Z6Y FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.81Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4z6y FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4z6y OCA], [https://pdbe.org/4z6y PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4z6y RCSB], [https://www.ebi.ac.uk/pdbsum/4z6y PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4z6y ProSAT]</span></td></tr> |
| - | [[Category: | + | </table> |
| - | [[Category: Gai | + | == Function == |
| + | [https://www.uniprot.org/uniprot/TBCD7_HUMAN TBCD7_HUMAN] Component of the TSC-TBC complex, that contains TBC1D7 in addition to the TSC1-TSC2 complex and consists of the functional complex possessing GTPase-activating protein (GAP) activity toward RHEB in response to alterations in specific cellular growth conditions. The small GTPase RHEB is a direct activator of the protein kinase activity of mTORC1 and the TSC-TBC complex acts as a negative regulator of mTORC1 signaling cascade by acting as a GAP for RHEB. Participates in the proper sensing of growth factors and glucose, but not amino acids, by mTORC1. It is unclear whether TBC1D7 acts as a GTPase-activating protein and additional studies are required to answer this question.<ref>PMID:22795129</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Gai Z]] | ||
| + | [[Category: Wu G]] | ||
Current revision
Structure of the TBC1D7-TSC1 complex
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