|
|
| (3 intermediate revisions not shown.) |
| Line 1: |
Line 1: |
| - | ==Crystal structure of the human adiponectin receptor 1==
| + | #REDIRECT [[6ks0]] This PDB entry is obsolete and replaced by 6ks0 |
| - | <StructureSection load='3wxv' size='340' side='right' caption='[[3wxv]], [[Resolution|resolution]] 2.90Å' scene=''>
| + | |
| - | == Structural highlights ==
| + | |
| - | <table><tr><td colspan='2'>[[3wxv]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WXV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WXV FirstGlance]. <br>
| + | |
| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
| + | |
| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3wxw|3wxw]]</td></tr>
| + | |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wxv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wxv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wxv RCSB], [http://www.ebi.ac.uk/pdbsum/3wxv PDBsum]</span></td></tr>
| + | |
| - | </table>
| + | |
| - | == Function ==
| + | |
| - | [[http://www.uniprot.org/uniprot/ADR1_HUMAN ADR1_HUMAN]] Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some high-affinity receptor for globular adiponectin but low-affinity receptor for full-length adiponectin.<ref>PMID:12802337</ref>
| + | |
| - | == References ==
| + | |
| - | <references/>
| + | |
| - | __TOC__
| + | |
| - | </StructureSection>
| + | |
| - | [[Category: Fujii, Y]]
| + | |
| - | [[Category: Hosaka, T]]
| + | |
| - | [[Category: Iwabu, M]]
| + | |
| - | [[Category: Kadowaki, T]]
| + | |
| - | [[Category: Kimura-Someya, T]]
| + | |
| - | [[Category: Nakamura, Y]]
| + | |
| - | [[Category: Okada-Iwabu, M]]
| + | |
| - | [[Category: Shirouzu, M]]
| + | |
| - | [[Category: Tanabe, H]]
| + | |
| - | [[Category: Yamauchi, T]]
| + | |
| - | [[Category: Yokoyama, S]]
| + | |
| - | [[Category: Adiponectin]]
| + | |
| - | [[Category: Appl1]]
| + | |
| - | [[Category: Appl2]]
| + | |
| - | [[Category: Membrane]]
| + | |
| - | [[Category: Membrane protein-immune system complex]]
| + | |
| - | [[Category: Osmotin]]
| + | |
| - | [[Category: Paqr family]]
| + | |
