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| - | ==Crystal structure of the human adiponectin receptor 2==
| + | #REDIRECT [[6ks1]] This PDB entry is obsolete and replaced by 6ks1 |
| - | <StructureSection load='3wxw' size='340' side='right' caption='[[3wxw]], [[Resolution|resolution]] 2.40Å' scene=''>
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| - | == Structural highlights ==
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| - | <table><tr><td colspan='2'>[[3wxw]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3WXW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3WXW FirstGlance]. <br>
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| - | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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| - | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3wxv|3wxv]]</td></tr>
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| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3wxw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3wxw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3wxw RCSB], [http://www.ebi.ac.uk/pdbsum/3wxw PDBsum]</span></td></tr>
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| - | </table>
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| - | == Function ==
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| - | [[http://www.uniprot.org/uniprot/ADR2_HUMAN ADR2_HUMAN]] Receptor for globular and full-length adiponectin (APM1), an essential hormone secreted by adipocytes that acts as an antidiabetic. Probably involved in metabolic pathways that regulate lipid metabolism such as fatty acid oxidation. Mediates increased AMPK, PPARA ligand activity, fatty acid oxidation and glucose uptake by adiponectin. Has some intermediate-affinity receptor activity for both globular and full-length adiponectin.<ref>PMID:12802337</ref>
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| - | == References ==
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| - | <references/>
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| - | __TOC__
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| - | </StructureSection>
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| - | [[Category: Fujii, Y]]
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| - | [[Category: Hosaka, T]]
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| - | [[Category: Iwabu, M]]
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| - | [[Category: Kadowaki, T]]
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| - | [[Category: Kimura-Someya, T]]
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| - | [[Category: Nakamura, Y]]
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| - | [[Category: Okada-Iwabu, M]]
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| - | [[Category: Shirouzu, M]]
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| - | [[Category: Tanabe, H]]
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| - | [[Category: Yamauchi, T]]
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| - | [[Category: Yokoyama, S]]
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| - | [[Category: Adiponectin]]
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| - | [[Category: Appl1]]
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| - | [[Category: Appl2]]
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| - | [[Category: Glucose and lipid metabolism]]
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| - | [[Category: Membrane]]
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| - | [[Category: Membrane protein-immune system complex]]
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| - | [[Category: Osmotin]]
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| - | [[Category: Paqr family]]
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