This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
2wwe
From Proteopedia
(Difference between revisions)
| (5 intermediate revisions not shown.) | |||
| Line 1: | Line 1: | ||
| + | |||
==Crystal structure of the phox homology domain of human phosphoinositide-3-kinase-C2-gamma== | ==Crystal structure of the phox homology domain of human phosphoinositide-3-kinase-C2-gamma== | ||
| - | <StructureSection load='2wwe' size='340' side='right' caption='[[2wwe]], [[Resolution|resolution]] 1.25Å' scene=''> | + | <StructureSection load='2wwe' size='340' side='right'caption='[[2wwe]], [[Resolution|resolution]] 1.25Å' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2wwe]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[2wwe]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WWE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WWE FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.25Å</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wwe OCA], [https://pdbe.org/2wwe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wwe RCSB], [https://www.ebi.ac.uk/pdbsum/2wwe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wwe ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/P3C2G_HUMAN P3C2G_HUMAN] Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers (By similarity). May play a role in SDF1A-stimulated chemotaxis (By similarity).[UniProtKB:O70167][UniProtKB:O70173] | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
| - | <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ww/2wwe_consurf.spt"</scriptWhenChecked> | + | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ww/2wwe_consurf.spt"</scriptWhenChecked> |
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wwe ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
==See Also== | ==See Also== | ||
| - | *[[Phosphoinositide 3- | + | *[[Phosphoinositide 3-kinase 3D structures|Phosphoinositide 3-kinase 3D structures]] |
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
| - | [[Category: | + | [[Category: Large Structures]] |
| - | [[Category: | + | [[Category: Arrowsmith CH]] |
| - | [[Category: Berglund | + | [[Category: Berglund H]] |
| - | [[Category: Bountra | + | [[Category: Bountra C]] |
| - | [[Category: Collins | + | [[Category: Collins R]] |
| - | [[Category: Edwards | + | [[Category: Edwards AM]] |
| - | [[Category: Flodin | + | [[Category: Flodin S]] |
| - | [[Category: Flores | + | [[Category: Flores A]] |
| - | [[Category: Graslund | + | [[Category: Graslund S]] |
| - | [[Category: Hammarstrom | + | [[Category: Hammarstrom M]] |
| - | [[Category: Johansson | + | [[Category: Johansson A]] |
| - | [[Category: Johansson | + | [[Category: Johansson I]] |
| - | [[Category: Kallas | + | [[Category: Kallas A]] |
| - | [[Category: Karlberg | + | [[Category: Karlberg T]] |
| - | [[Category: Kotyenova | + | [[Category: Kotyenova T]] |
| - | [[Category: Kotzch | + | [[Category: Kotzch A]] |
| - | [[Category: Kraulis | + | [[Category: Kraulis P]] |
| - | [[Category: Markova | + | [[Category: Markova N]] |
| - | [[Category: Moche | + | [[Category: Moche M]] |
| - | [[Category: Nielsen | + | [[Category: Nielsen TK]] |
| - | [[Category: Nordlund | + | [[Category: Nordlund P]] |
| - | [[Category: Nyman | + | [[Category: Nyman T]] |
| - | [[Category: Persson | + | [[Category: Persson C]] |
| - | [[Category: Roos | + | [[Category: Roos AK]] |
| - | + | [[Category: Schuler H]] | |
| - | [[Category: Schuler | + | [[Category: Schutz P]] |
| - | [[Category: Schutz | + | [[Category: Siponen MI]] |
| - | [[Category: Siponen | + | [[Category: Svensson L]] |
| - | [[Category: Svensson | + | [[Category: Thorsell AG]] |
| - | [[Category: Thorsell | + | [[Category: Tresaugues L]] |
| - | [[Category: Tresaugues | + | [[Category: Van Der Berg S]] |
| - | [[Category: Wahlberg | + | [[Category: Wahlberg E]] |
| - | [[Category: Weigelt | + | [[Category: Weigelt J]] |
| - | [[Category: Welin | + | [[Category: Welin M]] |
| - | [[Category: Wisniewska | + | [[Category: Wisniewska M]] |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Crystal structure of the phox homology domain of human phosphoinositide-3-kinase-C2-gamma
| |||||||||||
Categories: Homo sapiens | Large Structures | Arrowsmith CH | Berglund H | Bountra C | Collins R | Edwards AM | Flodin S | Flores A | Graslund S | Hammarstrom M | Johansson A | Johansson I | Kallas A | Karlberg T | Kotyenova T | Kotzch A | Kraulis P | Markova N | Moche M | Nielsen TK | Nordlund P | Nyman T | Persson C | Roos AK | Schuler H | Schutz P | Siponen MI | Svensson L | Thorsell AG | Tresaugues L | Van Der Berg S | Wahlberg E | Weigelt J | Welin M | Wisniewska M
