4zc9
From Proteopedia
(Difference between revisions)
(New page: '''Unreleased structure''' The entry 4zc9 is ON HOLD Authors: Seo, H.-S., DeAngelo, S., Bradner, J.E. Description: Crystal Structure of the BRD4a/DB-2-190 complex [[Category: Unrelease...) |
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal Structure of the BRD4a/DB-2-190 complex== | |
| + | <StructureSection load='4zc9' size='340' side='right'caption='[[4zc9]], [[Resolution|resolution]] 0.99Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4zc9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZC9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZC9 FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 0.99Å</td></tr> | ||
| + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4MW:2-[(6S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl]-N-(4-{[({2-[(3S)-2,6-dioxopiperidin-3-yl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}oxy)acetyl]amino}butyl)acetamide'>4MW</scene></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zc9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zc9 OCA], [https://pdbe.org/4zc9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zc9 RCSB], [https://www.ebi.ac.uk/pdbsum/4zc9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zc9 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | ||
| - | + | ==See Also== | |
| - | + | *[[Bromodomain-containing protein 3D structures|Bromodomain-containing protein 3D structures]] | |
| - | + | == References == | |
| - | [[Category: | + | <references/> |
| - | [[Category: | + | __TOC__ |
| - | [[Category: | + | </StructureSection> |
| - | [[Category: | + | [[Category: Homo sapiens]] |
| + | [[Category: Large Structures]] | ||
| + | [[Category: Bradner JE]] | ||
| + | [[Category: DeAngelo S]] | ||
| + | [[Category: Seo H-S]] | ||
Current revision
Crystal Structure of the BRD4a/DB-2-190 complex
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