4r7p

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==Human UDP-glucose pyrophosphorylase isoform 1 in complex with UDP-glucose==
==Human UDP-glucose pyrophosphorylase isoform 1 in complex with UDP-glucose==
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<StructureSection load='4r7p' size='340' side='right' caption='[[4r7p]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
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<StructureSection load='4r7p' size='340' side='right'caption='[[4r7p]], [[Resolution|resolution]] 3.35&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[4r7p]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R7P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4R7P FirstGlance]. <br>
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<table><tr><td colspan='2'>[[4r7p]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4R7P OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4R7P FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UPG:URIDINE-5-DIPHOSPHATE-GLUCOSE'>UPG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.35&#8491;</td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3r2w|3r2w]], [[3r3i|3r3i]]</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UPG:URIDINE-5-DIPHOSPHATE-GLUCOSE'>UPG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/UTP--glucose-1-phosphate_uridylyltransferase UTP--glucose-1-phosphate uridylyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.9 2.7.7.9] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4r7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r7p OCA], [https://pdbe.org/4r7p PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4r7p RCSB], [https://www.ebi.ac.uk/pdbsum/4r7p PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4r7p ProSAT]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4r7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4r7p OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4r7p RCSB], [http://www.ebi.ac.uk/pdbsum/4r7p PDBsum]</span></td></tr>
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</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/UGPA_HUMAN UGPA_HUMAN]] Plays a central role as a glucosyl donor in cellular metabolic pathways.
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[https://www.uniprot.org/uniprot/UGPA_HUMAN UGPA_HUMAN] Plays a central role as a glucosyl donor in cellular metabolic pathways.
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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In mammals, UDP-glucose pyrophosphorylase (UGP) is the only enzyme capable of activating glucose-1-phosphate (Glc-1-P) to UDP-glucose (UDP-Glc), a metabolite located at the intersection of virtually all metabolic pathways in the mammalian cell. Despite the essential role of its product, the molecular basis of UGP function is poorly understood. Here we report the crystal structure of human UGP in complex with its product UDP-Glc. Beyond providing first insight into the active site architecture, we describe the substrate binding mode and intermolecular interactions in the octameric enzyme that are crucial to its activity. Importantly, the quaternary mechanism identified for human UGP in this study may be common for oligomeric sugar-activating nucleotidyltransferases. Elucidating such mechanisms is essential for understanding nucleotide sugar metabolism and opens the perspective for the development of drugs that specifically inhibit simpler organized nucleotidyltransferases in pathogens.
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A Quaternary Mechanism Enables the Complex Biological Functions of Octameric Human UDP-glucose Pyrophosphorylase, a Key Enzyme in Cell Metabolism.,Fuhring JI, Cramer JT, Schneider J, Baruch P, Gerardy-Schahn R, Fedorov R Sci Rep. 2015 Apr 10;5:9618. doi: 10.1038/srep09618. PMID:25860585<ref>PMID:25860585</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: UTP--glucose-1-phosphate uridylyltransferase]]
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[[Category: Homo sapiens]]
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[[Category: Baruch, P]]
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[[Category: Large Structures]]
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[[Category: Cramer, J T]]
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[[Category: Baruch P]]
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[[Category: Fedorov, R]]
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[[Category: Cramer JT]]
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[[Category: Fuehring, J]]
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[[Category: Fedorov R]]
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[[Category: Gerardy-Schahn, R]]
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[[Category: Fuehring J]]
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[[Category: Schneider, J]]
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[[Category: Gerardy-Schahn R]]
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[[Category: Glc-1-p]]
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[[Category: Schneider J]]
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[[Category: Pyrophosphorylase]]
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[[Category: Rossmann-like alpha/beta/alpha sandwich fold]]
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[[Category: Transferase]]
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[[Category: Utp]]
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Current revision

Human UDP-glucose pyrophosphorylase isoform 1 in complex with UDP-glucose

PDB ID 4r7p

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