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2vdv

From Proteopedia

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[[Image:2vdv.jpg|left|200px]]
 
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{{Structure
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==Structure of trm8, m7G methylation enzyme==
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|PDB= 2vdv |SIZE=350|CAPTION= <scene name='initialview01'>2vdv</scene>, resolution 2.3&Aring;
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<StructureSection load='2vdv' size='340' side='right'caption='[[2vdv]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:Sam+Binding+Site+For+Chain+E'>AC1</scene> and <scene name='pdbsite=AC2:Sam+Binding+Site+For+Chain+F'>AC2</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene>
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<table><tr><td colspan='2'>[[2vdv]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VDV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VDV FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/tRNA_(guanine-N(7)-)-methyltransferase tRNA (guanine-N(7)-)-methyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.1.1.33 2.1.1.33]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SAM:S-ADENOSYLMETHIONINE'>SAM</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vdv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vdv OCA], [https://pdbe.org/2vdv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vdv RCSB], [https://www.ebi.ac.uk/pdbsum/2vdv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vdv ProSAT]</span></td></tr>
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</table>
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== Function ==
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[https://www.uniprot.org/uniprot/TRMB_YEAST TRMB_YEAST] Methyltransferase that catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA, a modification required to maintain stability of tRNAs; its absence resulting in tRNA decay. Both the D-stem and T-stem structures of tRNAs are required for efficient methyltransferase activity.[HAMAP-Rule:MF_03055]<ref>PMID:16387656</ref> <ref>PMID:17382321</ref>
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== Evolutionary Conservation ==
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[[Image:Consurf_key_small.gif|200px|right]]
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Check<jmol>
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<jmolCheckbox>
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vd/2vdv_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vdv ConSurf].
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<div style="clear:both"></div>
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'''STRUCTURE OF TRM8, M7G METHYLATION ENZYME'''
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==See Also==
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*[[TRNA methyltransferase 3D structures|TRNA methyltransferase 3D structures]]
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== References ==
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==About this Structure==
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<references/>
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2VDV is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VDV OCA].
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Single protein]]
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[[Category: Blondeau K]]
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[[Category: tRNA (guanine-N(7)-)-methyltransferase]]
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[[Category: Chaillet M]]
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[[Category: Blondeau, K.]]
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[[Category: Durand D]]
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[[Category: Chaillet, M.]]
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[[Category: Leulliot N]]
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[[Category: Durand, D.]]
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[[Category: Ulryck N]]
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[[Category: Leulliot, N.]]
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[[Category: Van Tilbeurgh H]]
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[[Category: Tilbeurgh, H Van.]]
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[[Category: Ulryck, N.]]
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[[Category: SAM]]
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[[Category: m7g]]
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[[Category: methyltransferase]]
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[[Category: phosphorylation]]
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[[Category: s-adenosyl-l-methionine]]
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[[Category: spout mt]]
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[[Category: transferase]]
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[[Category: trna]]
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[[Category: trna processing]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:45:41 2008''
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Current revision

Structure of trm8, m7G methylation enzyme

PDB ID 2vdv

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