4s0h
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==TBX5 DB, NKX2.5 HD, ANF DNA Complex== | |
| + | <StructureSection load='4s0h' size='340' side='right'caption='[[4s0h]], [[Resolution|resolution]] 2.82Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[4s0h]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S0H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4S0H FirstGlance]. <br> | ||
| + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.817Å</td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4s0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s0h OCA], [https://pdbe.org/4s0h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4s0h RCSB], [https://www.ebi.ac.uk/pdbsum/4s0h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4s0h ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/TBX5_HUMAN TBX5_HUMAN] Holt-Oram syndrome. The disease is caused by mutations affecting the gene represented in this entry. Defects in TBX5 are associated with susceptibility to dilated cardiomyopathy (DCM). A disorder characterized by ventricular and impaired systolic function, resulting in heart failure and arrhythmia. Patient are at risk of premature death.<ref>PMID:25725155</ref> <ref>PMID:25963046</ref> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/TBX5_HUMAN TBX5_HUMAN] DNA-binding protein that regulates the transcription of several genes and is involved in heart development and limb pattern formation.<ref>PMID:25725155</ref> <ref>PMID:25963046</ref> <ref>PMID:8988164</ref> | ||
| - | + | ==See Also== | |
| - | + | *[[NKX2.5 Homeodomain|NKX2.5 Homeodomain]] | |
| - | + | *[[T-box proteins|T-box proteins]] | |
| - | [[Category: | + | == References == |
| - | [[Category: Pradhan | + | <references/> |
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Synthetic construct]] | ||
| + | [[Category: Pradhan L]] | ||
Current revision
TBX5 DB, NKX2.5 HD, ANF DNA Complex
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