2vkn

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[[Image:2vkn.jpg|left|200px]]
 
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{{Structure
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==YEAST SHO1 SH3 DOMAIN COMPLEXED WITH A PEPTIDE FROM PBS2==
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|PDB= 2vkn |SIZE=350|CAPTION= <scene name='initialview01'>2vkn</scene>, resolution 2.05&Aring;
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<StructureSection load='2vkn' size='340' side='right'caption='[[2vkn]], [[Resolution|resolution]] 2.05&Aring;' scene=''>
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|SITE= <scene name='pdbsite=AC1:So4+Binding+Site+For+Chain+A'>AC1</scene>, <scene name='pdbsite=AC2:So4+Binding+Site+For+Chain+C'>AC2</scene> and <scene name='pdbsite=AC3:So4+Binding+Site+For+Chain+C'>AC3</scene>
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== Structural highlights ==
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|LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene>
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<table><tr><td colspan='2'>[[2vkn]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2qk6 2qk6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VKN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2VKN FirstGlance]. <br>
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|ACTIVITY= [http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase_kinase Mitogen-activated protein kinase kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.12.2 2.7.12.2]
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05&#8491;</td></tr>
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|GENE=
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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}}
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2vkn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2vkn OCA], [https://pdbe.org/2vkn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2vkn RCSB], [https://www.ebi.ac.uk/pdbsum/2vkn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2vkn ProSAT]</span></td></tr>
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</table>
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'''YEAST SHO1 SH3 DOMAIN COMPLEXED WITH A PEPTIDE FROM PBS2'''
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== Function ==
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[https://www.uniprot.org/uniprot/SHO1_YEAST SHO1_YEAST] Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity. Detects changes in external osmolarity and activates PBS2 through the stimulation of STE11 and targets PBS2 to the plasma membrane. PBS2 activation leads to changes in glycerol production that helps to balance the intracellular and external osmotic pressures. Activates also HOG1 in response to heat stress and mediates resistance to oxidative stress. Involved in the regulation of the mating pathway. May be a receptor that feeds into the pseudohyphal growth pathway.<ref>PMID:10762242</ref> <ref>PMID:10931333</ref> <ref>PMID:10970855</ref> <ref>PMID:10980703</ref> <ref>PMID:11084293</ref> <ref>PMID:11922108</ref> <ref>PMID:12455951</ref> <ref>PMID:12511654</ref> <ref>PMID:14595107</ref> <ref>PMID:15020407</ref> <ref>PMID:15200958</ref> <ref>PMID:15200959</ref> <ref>PMID:15256499</ref> <ref>PMID:16778768</ref> <ref>PMID:18480263</ref> <ref>PMID:19318625</ref> <ref>PMID:19439450</ref> <ref>PMID:7624781</ref> <ref>PMID:9180081</ref> <ref>PMID:9744864</ref>
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== Evolutionary Conservation ==
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==About this Structure==
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[[Image:Consurf_key_small.gif|200px|right]]
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2VKN is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. This structure supersedes the now removed PDB entry 2QK6. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2VKN OCA].
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Check<jmol>
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[[Category: Mitogen-activated protein kinase kinase]]
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<jmolCheckbox>
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[[Category: Protein complex]]
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<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/vk/2vkn_consurf.spt"</scriptWhenChecked>
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<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
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<text>to colour the structure by Evolutionary Conservation</text>
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</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2vkn ConSurf].
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<div style="clear:both"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Large Structures]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Saccharomyces cerevisiae]]
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[[Category: Kursula, I.]]
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[[Category: Kursula I]]
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[[Category: Kursula, P.]]
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[[Category: Kursula P]]
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[[Category: Paraskevopoulos, K.]]
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[[Category: Paraskevopoulos K]]
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[[Category: Song, Y H.]]
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[[Category: Song YH]]
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[[Category: Wilmanns, M.]]
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[[Category: Wilmanns M]]
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[[Category: SO4]]
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[[Category: membrane]]
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[[Category: membrane protein]]
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[[Category: peptide]]
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[[Category: s. cerevisiae]]
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[[Category: sh3 domain]]
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[[Category: transmembrane]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:47:25 2008''
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Current revision

YEAST SHO1 SH3 DOMAIN COMPLEXED WITH A PEPTIDE FROM PBS2

PDB ID 2vkn

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